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크립토코쿠스 수막염 : 일개 대학병원에서 최근 12년간의 경험

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dc.contributor.author한상훈-
dc.contributor.author김준명-
dc.contributor.author김창오-
dc.contributor.author백지현-
dc.contributor.author송영구-
dc.contributor.author정수진-
dc.contributor.author진범식-
dc.contributor.author진성준-
dc.contributor.author채윤태-
dc.contributor.author최준용-
dc.date.accessioned2015-04-23T17:40:59Z-
dc.date.available2015-04-23T17:40:59Z-
dc.date.issued2010-
dc.identifier.issn1598-8112-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102929-
dc.description.abstractBACKGROUND: Cryptococcal infections are frequent in human immunodeficiency virus (HIV)-infected patients. This infection may occur in other immunocompromised patients, and the diagnosis is often delayed in these cases. There are a few reports on cryptococcal meningitis in non-HIV-infected patients in Korea. We reviewed the clinical features and efficacy of antifungal therapy in 33 patients who were treated at a single tertiary health care center of Korea. MATERIALS AND METHODS: The medical records of 33 consecutive patients who were admitted to one tertiary hospital for cryptococcal meningitis between 1995 and 2008 were reviewed retrospectively. Cryptococcal meningitis was confirmed by positive cerebral spinal fluid (CSF) cultures or compatible clinical features plus a positive cryptococcal antigen test of CSF. RESULTS: Of the 33 patients analyzed, 30 cases were non-HIV patients. The outcomes were complete cure in 23 cases, relapse after initial treatment in four cases, and death due to treatment failure in six cases. The main initial manifestations were headache (84.8%), fever (54.5%), and seizure (33.3%). Factors significantly associated with unfavorable outcomes, including mortality and relapse, were afebrile condition, mental change, hearing impairment, initial high opening pressure of CSF (>250 mmH2O), and low initial absolute neutrophil count. On multivariate analysis, afebrile condition was an independent predictor of an unfavorable outcome (odds ratio 17.3; 95% confidence interval 1.0-28.3; P=0.045). CONCLUSIONS: It is necessary to observe closely cryptococcal meningitis patients without fever on admission-
dc.description.statementOfResponsibilityopen-
dc.format.extent285~290-
dc.relation.isPartOfINFECTION AND CHEMOTHERAPY (감염과 화학요법)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.title크립토코쿠스 수막염 : 일개 대학병원에서 최근 12년간의 경험-
dc.title.alternativeCryptococcal Meningitis : 12 Years Experience in a Single Tertiary Health Care Center-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorYun Tae Chae-
dc.contributor.googleauthorSung Joon Jin-
dc.contributor.googleauthorJi-hyeon Baek-
dc.contributor.googleauthorBum Sik Chin-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.3947/ic.2010.42.5.285-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04286-
dc.contributor.localIdA00953-
dc.contributor.localIdA01044-
dc.contributor.localIdA01839-
dc.contributor.localIdA02037-
dc.contributor.localIdA03638-
dc.contributor.localIdA03981-
dc.contributor.localIdA03983-
dc.contributor.localIdA04022-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ01054-
dc.subject.keywordCryptococcal infection-
dc.subject.keywordCryptococcal meningitis-
dc.subject.keywordFever-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameBaek, Ji Hyeon-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChin, Bum Sik-
dc.contributor.alternativeNameJin, Sung Joon-
dc.contributor.alternativeNameChae, Yun Tae-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorBaek, Ji Hyeon-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChin, Bum Sik-
dc.contributor.affiliatedAuthorJin, Sung Joon-
dc.contributor.affiliatedAuthorChae, Yun Tae-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.citation.volume42-
dc.citation.number5-
dc.citation.startPage285-
dc.citation.endPage290-
dc.identifier.bibliographicCitationINFECTION AND CHEMOTHERAPY (감염과 화학요법), Vol.42(5) : 285-290, 2010-
dc.identifier.rimsid35100-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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