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Use of contrast enhancement and high-resolution 3D black-blood MRI to identify inflammation in atherosclerosis

Authors
 Jin Hur  ;  Jaeseok Park  ;  Young Jin Kim  ;  Hye-Jeong Lee  ;  Hyo Sup Shim  ;  Kyu Ok Choe  ;  Byoung Wook Choi 
Citation
 JACC-CARDIOVASCULAR IMAGING, Vol.3(11) : 1127-1135, 2010 
Journal Title
 JACC-CARDIOVASCULAR IMAGING 
ISSN
 1936-878X 
Issue Date
2010
MeSH
Animals ; Aortic Diseases/metabolism ; Aortic Diseases/pathology* ; Atherosclerosis/metabolism ; Atherosclerosis/pathology* ; Contrast Media* ; Disease Models, Animal ; Fibrosis ; Gadolinium DTPA* ; Image Interpretation, Computer-Assisted ; Imaging, Three-Dimensional* ; Inflammation/metabolism ; Inflammation/pathology* ; Linear Models ; Lipids/analysis ; Macrophages/pathology ; Magnetic Resonance Imaging/methods* ; Male ; Microvessels/pathology ; Predictive Value of Tests ; Rabbits
Keywords
atherosclerosis ; inflammation ; magnetic resonance imaging ; plaque
Abstract
OBJECTIVES: We investigated the contributing factors for plaque enhancement and examined the relationships between regional contrast enhancement and the inflammatory activity of atherosclerotic plaques in an experimental rabbit model using contrast-enhanced high-resolution 3-dimensional (3D) black-blood magnetic resonance imaging (MRI) in comparison with histopathologic analysis. BACKGROUND: Inflammation plays a critical role in plaque initiation, progression, and disruption. As such, inflammation represents an emerging target for the treatment of atherosclerosis. MRI findings suggest that contrast agent-induced signal enhancement is associated with the degree of macrophage infiltration and neovessels that can be detected in plaque. METHODS: Ten atherosclerotic rabbits and 3 normal control rabbits underwent high-resolution 3D contrast-enhanced black-blood MRI. Magnetic resonance images and the corresponding histopathologic sections were divided into 4 quadrants. Plaque composition was analyzed for each quadrant according to histopathologic criteria (percent of lipid-rich, fibrous, macrophage area and microvessel density) and imaging criteria (enhancement ratio [ER], ER = signal intensity(post)/signal intensity(pre)). Multiple linear regression analysis was performed to determine independent factors for plaque enhancement. RESULTS: A total of 62 noncalcified plaques (n = 248; 156 lipid-rich quadrants and 92 fibrous quadrants) were identified based on histopathologic analysis. Mean ER values were significantly higher in atherosclerotic vessel walls than in normal vessel walls (2.03 ± 0.25 vs. 1.58 ± 0.15; p = 0.017). The mean ER values were significantly higher in lipid-rich quadrants compared with the fibrous quadrants (2.14 ± 0.31 vs. 1.84 ± 0.21; p = 0.001). Mean ER values were significantly higher in macrophage-rich plaques compared with the macrophage-poor plaques (2.21 ± 0.28 vs. 1.81 ± 0.22; p = 0.001). Using multiple regression analysis, macrophage area and microvessel density were associated independently with ER values that reflected plaque enhancement (p < 0.001). CONCLUSIONS: Contrast-enhanced high-resolution 3D black-blood MRI may be an efficient method to detect plaque inflammation
DOI
10.1016/j.jcmg.2010.08.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Park, Jae Seok(박재석)
Shim, Hyo Sup(심효섭) ORCID logo https://orcid.org/0000-0002-5718-3624
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Choe, Kyu Ok(최규옥)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102805
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