1202 689

Cited 0 times in

백혈구연층법으로 분리 제조한 농축적혈구, 혼합혈소판 및 동결혈장 제제의 품질 평가

Other Titles
 Quality Assessment of Red Blood Cells, Pooled Platelets and Frozen Plasma Processed by the Buffy Coat Method 
Authors
 홍덕진  ;  최승준  ;  김신영  ;  김현옥  ;  박규은 
Citation
 Korean Journal of Blood Transfusion, Vol.21(3) : 254-265, 2010 
Journal Title
Korean Journal of Blood Transfusion(대한수혈학회지)
ISSN
 1226-9336 
Issue Date
2010
Keywords
Buffy coat method ; Blood separation ; Pooled platelet ; 24 hr frozen plasma
Abstract
Background: Buffy coat method is one of the blood components processing methods widely used in many countries including Europe and Canada. For the first time in Korea, we evaluated the qualities of blood components manufactured by buffy coat method. Methods: We collected 400 mL whole bloods using the quadruple top and bottom blood bag from thirty-five donors. Whole bloods were processed into leukoreduced RBC, leukoreduced pooled platelet, and 24 hr frozen plasma by the buffy coat method with blood bags and instruments of Fenwal and Fresenius. The qualities of each blood component were analyzed at each scheduled day, and compared with the standard guidelines of quality control in Korean Red Cross. Results: The volume and hemoglobin of RBCs were lower than the standard guidelines. Comparing with the standard of apheresis platelets, leukoreduced pooled platelets showed higher total platelet yield with the median 3.70×1011/unit. Frozen plasma showed increased volume recovery than the standard guideline, but the activity of factor VIII at Day 35 was decreased to 0.66±0.14 IU/mL. Conclusion: We have found that the yields of pooled platelet and the frozen plasma processed by buffy coat method were higher than the standard guidelines. To introduce the buffy coat method to routine blood component separation process in Korea, further evaluations about the cost-effectiveness of buffy coat method are required.
Files in This Item:
T201004161.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Choi, Seung Jun(최승준) ORCID logo https://orcid.org/0000-0003-0736-1055
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102651
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links