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Predictors of response after intravitreal bevacizumab injection for neovascular age-related macular degeneration

Authors
 Yeo Jue Byun  ;  Sung Jun Lee  ;  Hyoung Jun Koh 
Citation
 JAPANESE JOURNAL OF OPHTHALMOLOGY, Vol.54(6) : 571-577, 2010 
Journal Title
 JAPANESE JOURNAL OF OPHTHALMOLOGY 
ISSN
 0021-5155 
Issue Date
2010
MeSH
Aged ; Angiogenesis Inhibitors/administration & dosage* ; Antibodies, Monoclonal/administration & dosage* ; Antibodies, Monoclonal, Humanized ; Bevacizumab ; Choroidal Neovascularization/diagnosis ; Choroidal Neovascularization/drug therapy* ; Choroidal Neovascularization/physiopathology ; Female ; Fluorescein Angiography ; Humans ; Intravitreal Injections ; Macular Degeneration/diagnosis ; Macular Degeneration/drug therapy* ; Macular Degeneration/physiopathology ; Male ; Retreatment ; Retrospective Studies ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/physiology
Abstract
PURPOSE: To identify fluorescein angiography (FA) and optical coherence tomography (OCT) characteristics predicting responses to intravitreal bevacizumab therapy in patients with neovascular age-related macular degeneration (AMD). METHODS: Results of 113 consecutive patients (113 eyes) treated with intravitreal bevacizumab injections for neovascular AMD were retrospectively reviewed. Patients were categorized into two groups according to visual acuity (VA) improvement 1 year after treatment: responders and nonresponders. Responders were defined as patients who achieved VA improvement ≥7 Early Treatment Diabetic Retinopathy Study (ETDRS) letters for occult choroidal neovascularization (CNV), and ≥11 ETDRS letters for classic CNV at month 12. N onresponders were defined as patients who did not meet the above VA improvement at month 12. RESULTS: Of the 113 eyes, 36 (31.9%) were categorized as responders and 77 (68.1%) as nonresponders. Nonresponders, compared with responders, had thicker subretinal tissue (SRT) (218.9 μm versus 180.9 μm, P = 0.040), and more frequent cystoid macular edema (CME) (42.9% versus 13.9%, P < 0.001). CONCLUSION: Thick SRT and CME on OCT may be characteristic of nonresponders and may be helpful for tailoring treatment for neovascular AMD
Full Text
http://link.springer.com/article/10.1007%2Fs10384-010-0866-1
DOI
10.1007/s10384-010-0866-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hyoung Jun(고형준) ORCID logo https://orcid.org/0000-0002-5932-8516
Byun, Yeo Jue(변여주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102648
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