Cited 28 times in
Predictors of response after intravitreal bevacizumab injection for neovascular age-related macular degeneration
DC Field | Value | Language |
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dc.contributor.author | 고형준 | - |
dc.contributor.author | 변여주 | - |
dc.date.accessioned | 2015-04-23T17:31:59Z | - |
dc.date.available | 2015-04-23T17:31:59Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0021-5155 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102648 | - |
dc.description.abstract | PURPOSE: To identify fluorescein angiography (FA) and optical coherence tomography (OCT) characteristics predicting responses to intravitreal bevacizumab therapy in patients with neovascular age-related macular degeneration (AMD). METHODS: Results of 113 consecutive patients (113 eyes) treated with intravitreal bevacizumab injections for neovascular AMD were retrospectively reviewed. Patients were categorized into two groups according to visual acuity (VA) improvement 1 year after treatment: responders and nonresponders. Responders were defined as patients who achieved VA improvement ≥7 Early Treatment Diabetic Retinopathy Study (ETDRS) letters for occult choroidal neovascularization (CNV), and ≥11 ETDRS letters for classic CNV at month 12. N onresponders were defined as patients who did not meet the above VA improvement at month 12. RESULTS: Of the 113 eyes, 36 (31.9%) were categorized as responders and 77 (68.1%) as nonresponders. Nonresponders, compared with responders, had thicker subretinal tissue (SRT) (218.9 μm versus 180.9 μm, P = 0.040), and more frequent cystoid macular edema (CME) (42.9% versus 13.9%, P < 0.001). CONCLUSION: Thick SRT and CME on OCT may be characteristic of nonresponders and may be helpful for tailoring treatment for neovascular AMD | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 571~577 | - |
dc.relation.isPartOf | JAPANESE JOURNAL OF OPHTHALMOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angiogenesis Inhibitors/administration & dosage* | - |
dc.subject.MESH | Antibodies, Monoclonal/administration & dosage* | - |
dc.subject.MESH | Antibodies, Monoclonal, Humanized | - |
dc.subject.MESH | Bevacizumab | - |
dc.subject.MESH | Choroidal Neovascularization/diagnosis | - |
dc.subject.MESH | Choroidal Neovascularization/drug therapy* | - |
dc.subject.MESH | Choroidal Neovascularization/physiopathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorescein Angiography | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intravitreal Injections | - |
dc.subject.MESH | Macular Degeneration/diagnosis | - |
dc.subject.MESH | Macular Degeneration/drug therapy* | - |
dc.subject.MESH | Macular Degeneration/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Retreatment | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tomography, Optical Coherence | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/antagonists & inhibitors | - |
dc.subject.MESH | Visual Acuity/physiology | - |
dc.title | Predictors of response after intravitreal bevacizumab injection for neovascular age-related macular degeneration | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학) | - |
dc.contributor.googleauthor | Yeo Jue Byun | - |
dc.contributor.googleauthor | Sung Jun Lee | - |
dc.contributor.googleauthor | Hyoung Jun Koh | - |
dc.identifier.doi | 10.1007/s10384-010-0866-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00152 | - |
dc.contributor.localId | A01851 | - |
dc.relation.journalcode | J01209 | - |
dc.identifier.eissn | 1613-2246 | - |
dc.identifier.pmid | 21191718 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10384-010-0866-1 | - |
dc.contributor.alternativeName | Koh, Hyoung Jun | - |
dc.contributor.alternativeName | Byun, Yeo Jue | - |
dc.contributor.affiliatedAuthor | Koh, Hyoung Jun | - |
dc.contributor.affiliatedAuthor | Byun, Yeo Jue | - |
dc.citation.volume | 54 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 571 | - |
dc.citation.endPage | 577 | - |
dc.identifier.bibliographicCitation | JAPANESE JOURNAL OF OPHTHALMOLOGY, Vol.54(6) : 571-577, 2010 | - |
dc.identifier.rimsid | 55350 | - |
dc.type.rims | ART | - |
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