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Clinical manifestations of cerebellar infarction according to specific lobular involvement

Authors
 Byoung Seok Ye  ;  Young Dae Kim  ;  Hyo Suk Nam  ;  Hye Sun Lee  ;  Chung Mo Nam  ;  Ji Hoe Heo 
Citation
 CEREBELLUM, Vol.9(4) : 571-579, 2010 
Journal Title
 CEREBELLUM 
ISSN
 1473-4222 
Issue Date
2010
MeSH
Adult ; Aged ; Aged, 80 and over ; Ataxia/etiology ; Brain Mapping* ; Cerebellar Diseases/pathology* ; Cerebellar Diseases/physiopathology ; Cerebellum/pathology* ; Female ; Headache/etiology ; Humans ; Logistic Models ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Nystagmus, Pathologic/etiology ; Retrospective Studies ; Risk Factors ; Vertigo/etiology ; Young Adult
Abstract
Lesions in the cerebellum produce various symptoms related to balance and motor coordination. However, the relationship between the exact topographical localization of a lesion and the resulting symptoms is not well understood in humans. In this study, we analyzed 66 consecutive patients with isolated cerebellar infarctions demonstrated on diffusion-weighted magnetic resonance imaging. We identified the involved lobules in these patients using a cross-referencing tool of the picture archiving and communication system, and we investigated the relationships between the sites of the lesions and specific symptoms using χ (2) tests and logistic regression analysis. The most common symptoms in patients with isolated cerebellar infarctions were vertigo (87%) and lateropulsion (82%). Isolated vertigo or lateropulsion without any other symptoms was present in 38% of patients. On the other hand, limb ataxia was a presenting symptom in only 40% of the patients. Lateropulsion, vertigo, and nystagmus were more common in patients with a lesion in the caudal vermis. Logistic regression analysis showed that lesions in the posterior paravermis or nodulus were independently associated with lateropulsion. Lesions in the nodulus were associated with contralateral pulsion, and involvement of the culmen was associated with ipsilateral pulsion and isolated lateropulsion without vertigo. Nystagmus was associated with lesions in the pyramis lobule, while lesions of the anterior paravermis were associated with dysarthria and limb ataxia. Our results showed that the cerebellar lobules are responsible for producing specific symptoms in cerebellar stroke patients.
Full Text
http://link.springer.com/article/10.1007%2Fs12311-010-0200-y
DOI
10.1007/s12311-010-0200-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Dae(김영대) ORCID logo https://orcid.org/0000-0001-5750-2616
Nam, Jung Mo(남정모) ORCID logo https://orcid.org/0000-0003-0985-0928
Nam, Hyo Suk(남효석) ORCID logo https://orcid.org/0000-0002-4415-3995
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102594
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