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Characterisation of small hypoattenuating hepatic lesions in multi-detector CT (MDCT) in patients with underlying extrahepatic malignancy: added value of contrast-enhanced MR images.

 Song-Ee Baek  ;  Mi-Suk Park  ;  Hye Sook Hong  ;  Jin Young Choi  ;  Yong Eun Chung  ;  Joon Seok Lim  ;  Myeong-Jin Kim  ;  Ki Whang Kim 
 EUROPEAN RADIOLOGY, Vol.20(12) : 2853-2861, 2010 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Contrast Media ; Humans ; Image Enhancement/methods* ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/secondary* ; Magnetic Resonance Imaging/methods* ; Meglumine/analogs & derivatives* ; Middle Aged ; Organometallic Compounds* ; Reproducibility of Results ; Sensitivity and Specificity ; Subtraction Technique* ; Tomography, X-Ray Computed/methods*
Liver ; Metastasis ; Magnetic resonance ; Small hepatic lesion ; Computed tomography
OBJECTIVE: To retrospectively assess the value of adding gadolinium-enhanced dynamic imaging to standard ununenhanced magnetic resonance imaging (MRI) for characterising hypoattenuating hepatic lesions that are too small to characterise with multi-detector computed tomography (MDCT).

METHODS: Informed consent was waved, and institutional review board approval was obtained. Three hundred and forty-six small (≤ 2 cm) lesions (63 metastatic, 283 benign) in 183 patients with underlying carcinoma who underwent hepatic MRI after CT were retrospectively analysed. Two radiologists independently reviewed images and diagnoses were graded on an ordinal scale from 1 (definitely benign) to 5 (definitely malignant). Receiver operating characteristic analysis was used. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were also determined.

RESULTS: The areas under the curve of the ununenhanced images alone and with dynamic images were 0.837 and 0.850 for reader 1 (p = 0.616) and 0.771 and 0.783 for reader 2 (p = 0.700). Descriptive statistical values demonstrated sensitivities of 76% and 80%, specificities of 93% and 95%, PPVs of 69% and 79%, NPVs of 95% and 95% and accuracies of 90% and 92%, respectively.

CONCLUSION: The value of adding three-phase contrast-enhanced MRI to unenhanced imaging did not reach statistical significance for characterising small hypoattenuating hepatic lesions on MDCT.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Baek, Song Ee(백송이) ORCID logo https://orcid.org/0000-0001-8146-2570
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
Hong, Hye Suk(홍혜숙) ORCID logo https://orcid.org/0000-0001-7398-2517
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