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Acute electroacupuncture inhibits nitric oxide synthase expression in the spinal cord of neuropathic rats

Authors
 Myeoung Hoon Cha  ;  Sun Joon Bai  ;  Kyung Hee Lee  ;  Zang Hee Cho  ;  Young-Bo Kim  ;  Hye-Jung Lee  ;  Bae Hwan Lee 
Citation
 NEUROLOGICAL RESEARCH, Vol.32(SUPPL1) : 96-100, 2010 
Journal Title
 NEUROLOGICAL RESEARCH 
ISSN
 0161-6412 
Issue Date
2010
MeSH
Animals ; Electroacupuncture/methods* ; Immunohistochemistry ; Lumbar Vertebrae ; Male ; Neurons/metabolism ; Nitric Oxide Synthase Type I/antagonists & inhibitors ; Nitric Oxide Synthase Type I/metabolism* ; Pain/etiology ; Pain/metabolism ; Pain Management* ; Pain Measurement ; Peripheral Nervous System Diseases/metabolism ; Peripheral Nervous System Diseases/therapy* ; Physical Stimulation ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/metabolism* ; Sural Nerve/injuries ; Tibial Nerve/injuries ; Tibial Neuropathy/metabolism ; Tibial Neuropathy/therapy* ; Time Factors
Abstract
OBJECTIVES: To examine the effects of electroacupuncture stimulation on behavioral changes and neuronal nitric oxide synthase expression in the rat spinal cord after nerve injury. METHODS: Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery by tightly ligating and cutting the left tibial and sural nerves. Behavioral responses to mechanical stimulation were tested for 2 weeks post-operatively. At the end of behavioral testing, electroacupuncture stimulation was applied to ST36 (Choksamni) and SP9 (Eumleungcheon) acupoints. Immunocytochemical staining was performed to investigate changes in the expression of neuronal nitric oxide synthase-immunoreactive neurons in the L4-5 spinal cord. RESULTS: Mechanical allodynia was observed by nerve injury. The mechanical allodynia was decreased after electroacupuncture stimulation. Neuronal nitric oxide synthase expression was also decreased in L4-5 spinal cord by electroacupuncture treatment. DISCUSSION: These results suggest that electroacupuncture relieves mechanical allodynia in the neuropathic rats possibly by the inhibition of neuronal nitric oxide synthase expression in the spinal cord
Full Text
http://www.maneyonline.com/doi/abs/10.1179/016164109X12537002794363?queryID=34%2F182267&searchHistoryKey=
DOI
10.1179/016164109X12537002794363
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Lee, Kyung Hee(이경희)
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Cha, Myeoung Hoon(차명훈) ORCID logo https://orcid.org/0000-0002-7993-672X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102217
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