Cited 0 times in
Acute electroacupuncture inhibits nitric oxide synthase expression in the spinal cord of neuropathic rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이배환 | - |
dc.contributor.author | 차명훈 | - |
dc.contributor.author | 배선준 | - |
dc.contributor.author | 이경희 | - |
dc.date.accessioned | 2015-04-23T17:18:35Z | - |
dc.date.available | 2015-04-23T17:18:35Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0161-6412 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102217 | - |
dc.description.abstract | OBJECTIVES: To examine the effects of electroacupuncture stimulation on behavioral changes and neuronal nitric oxide synthase expression in the rat spinal cord after nerve injury. METHODS: Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery by tightly ligating and cutting the left tibial and sural nerves. Behavioral responses to mechanical stimulation were tested for 2 weeks post-operatively. At the end of behavioral testing, electroacupuncture stimulation was applied to ST36 (Choksamni) and SP9 (Eumleungcheon) acupoints. Immunocytochemical staining was performed to investigate changes in the expression of neuronal nitric oxide synthase-immunoreactive neurons in the L4-5 spinal cord. RESULTS: Mechanical allodynia was observed by nerve injury. The mechanical allodynia was decreased after electroacupuncture stimulation. Neuronal nitric oxide synthase expression was also decreased in L4-5 spinal cord by electroacupuncture treatment. DISCUSSION: These results suggest that electroacupuncture relieves mechanical allodynia in the neuropathic rats possibly by the inhibition of neuronal nitric oxide synthase expression in the spinal cord | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | S96~S100 | - |
dc.relation.isPartOf | NEUROLOGICAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Electroacupuncture/methods* | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Lumbar Vertebrae | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neurons/metabolism | - |
dc.subject.MESH | Nitric Oxide Synthase Type I/antagonists & inhibitors | - |
dc.subject.MESH | Nitric Oxide Synthase Type I/metabolism* | - |
dc.subject.MESH | Pain/etiology | - |
dc.subject.MESH | Pain/metabolism | - |
dc.subject.MESH | Pain Management* | - |
dc.subject.MESH | Pain Measurement | - |
dc.subject.MESH | Peripheral Nervous System Diseases/metabolism | - |
dc.subject.MESH | Peripheral Nervous System Diseases/therapy* | - |
dc.subject.MESH | Physical Stimulation | - |
dc.subject.MESH | Random Allocation | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Spinal Cord/metabolism* | - |
dc.subject.MESH | Sural Nerve/injuries | - |
dc.subject.MESH | Tibial Nerve/injuries | - |
dc.subject.MESH | Tibial Neuropathy/metabolism | - |
dc.subject.MESH | Tibial Neuropathy/therapy* | - |
dc.subject.MESH | Time Factors | - |
dc.title | Acute electroacupuncture inhibits nitric oxide synthase expression in the spinal cord of neuropathic rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Myeoung Hoon Cha | - |
dc.contributor.googleauthor | Sun Joon Bai | - |
dc.contributor.googleauthor | Kyung Hee Lee | - |
dc.contributor.googleauthor | Zang Hee Cho | - |
dc.contributor.googleauthor | Young-Bo Kim | - |
dc.contributor.googleauthor | Hye-Jung Lee | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.identifier.doi | 10.1179/016164109X12537002794363 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02791 | - |
dc.contributor.localId | A03994 | - |
dc.contributor.localId | A01795 | - |
dc.contributor.localId | A02662 | - |
dc.relation.journalcode | J02337 | - |
dc.identifier.eissn | 1743-1328 | - |
dc.identifier.pmid | 20034455 | - |
dc.identifier.url | http://www.maneyonline.com/doi/abs/10.1179/016164109X12537002794363?queryID=34%2F182267&searchHistoryKey= | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.alternativeName | Cha, Myeoung Hoon | - |
dc.contributor.alternativeName | Bai, Sun Joon | - |
dc.contributor.alternativeName | Lee, Kyung Hee | - |
dc.contributor.affiliatedAuthor | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | Cha, Myeoung Hoon | - |
dc.contributor.affiliatedAuthor | Bai, Sun Joon | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Hee | - |
dc.citation.volume | 32 | - |
dc.citation.number | SUPPL1 | - |
dc.citation.startPage | 96 | - |
dc.citation.endPage | 100 | - |
dc.identifier.bibliographicCitation | NEUROLOGICAL RESEARCH, Vol.32(SUPPL1) : 96-100, 2010 | - |
dc.identifier.rimsid | 51146 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.