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Perioperative administration of pregabalin for pain after robot-assisted endoscopic thyroidectomy: a randomized clinical trial

Authors
 So Yeon Kim  ;  Jong Ju Jeong  ;  Woong Youn Chung  ;  Hyun Joo Kim  ;  Kee-Hyun Nam  ;  Yon Hee Shim 
Citation
 SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol.24(11) : 2776-2781, 2010 
Journal Title
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
ISSN
 0930-2794 
Issue Date
2010
MeSH
Administration, Oral ; Adult ; Analgesics/administration & dosage* ; Double-Blind Method ; Endoscopy* ; Female ; Humans ; Male ; Middle Aged ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control* ; Perioperative Care* ; Postoperative Nausea and Vomiting/drug therapy ; Pregabalin ; Robotics* ; Thyroid Neoplasms/surgery* ; Thyroidectomy* ; Young Adult ; gamma-Aminobutyric Acid/administration & dosage ; gamma-Aminobutyric Acid/analogs & derivatives*
Abstract
BACKGROUND: Perioperative administration of pregabalin, which is effective for neuropathic pain, might reduce early postoperative and chronic pain. This randomized, double-blinded, placebo-controlled trial (Clinical Trials.gov ID NCT00905580) was designed to investigate the efficacy and safety of pregabalin for reducing both acute postoperative pain and the development of chronic pain in patients after robot-assisted endoscopic thyroidectomy. METHODS: Ninety-nine patients were randomly assigned to groups that received pregabalin 150 mg or placebo 1 h before surgery, with the dose repeated after 12 h. Assessments of pain and side effects were performed 48 h postoperatively. The incidences of chronic pain and hypoesthesia in the anterior chest were recorded 3 months after surgery. RESULTS: Ninety-four patients completed the study. Verbal numerical rating scale scores for pain and the need for additional analgesics were lower in the pregabalin group (n = 47) than the placebo group (n = 47) during 48 h postoperatively (P < 0.05). However, incidences of sedation and dizziness were higher in the pregabalin group (P < 0.05). There were no differences between the groups in the incidences of chronic pain and chest hypoesthesia at 3 months after surgery. CONCLUSIONS: Perioperative administration of pregabalin (150 mg twice per day) was effective in reducing early postoperative pain but not chronic pain in patients undergoing robot-assisted endoscopic thyroidectomy. Caution should be taken regarding dizziness and sedation
Full Text
http://link.springer.com/article/10.1007%2Fs00464-010-1045-7
DOI
10.1007/s00464-010-1045-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, So Yeon(김소연) ORCID logo https://orcid.org/0000-0001-5352-157X
Kim, Hyun Joo(김현주C)
Nam, Kee Hyun(남기현) ORCID logo https://orcid.org/0000-0002-6852-1190
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
Chung, Woong Youn(정웅윤)
Jeong, Jong Ju(정종주) ORCID logo https://orcid.org/0000-0002-4155-6035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102181
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