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Perioperative administration of pregabalin for pain after robot-assisted endoscopic thyroidectomy: a randomized clinical trial

DC FieldValueLanguage
dc.contributor.author심연희-
dc.contributor.author정웅윤-
dc.contributor.author정종주-
dc.contributor.author김소연-
dc.contributor.author김현주-
dc.contributor.author남기현-
dc.date.accessioned2015-04-23T17:17:27Z-
dc.date.available2015-04-23T17:17:27Z-
dc.date.issued2010-
dc.identifier.issn0930-2794-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102181-
dc.description.abstractBACKGROUND: Perioperative administration of pregabalin, which is effective for neuropathic pain, might reduce early postoperative and chronic pain. This randomized, double-blinded, placebo-controlled trial (Clinical Trials.gov ID NCT00905580) was designed to investigate the efficacy and safety of pregabalin for reducing both acute postoperative pain and the development of chronic pain in patients after robot-assisted endoscopic thyroidectomy. METHODS: Ninety-nine patients were randomly assigned to groups that received pregabalin 150 mg or placebo 1 h before surgery, with the dose repeated after 12 h. Assessments of pain and side effects were performed 48 h postoperatively. The incidences of chronic pain and hypoesthesia in the anterior chest were recorded 3 months after surgery. RESULTS: Ninety-four patients completed the study. Verbal numerical rating scale scores for pain and the need for additional analgesics were lower in the pregabalin group (n = 47) than the placebo group (n = 47) during 48 h postoperatively (P < 0.05). However, incidences of sedation and dizziness were higher in the pregabalin group (P < 0.05). There were no differences between the groups in the incidences of chronic pain and chest hypoesthesia at 3 months after surgery. CONCLUSIONS: Perioperative administration of pregabalin (150 mg twice per day) was effective in reducing early postoperative pain but not chronic pain in patients undergoing robot-assisted endoscopic thyroidectomy. Caution should be taken regarding dizziness and sedation-
dc.description.statementOfResponsibilityopen-
dc.format.extent2776~2781-
dc.relation.isPartOfSURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAdult-
dc.subject.MESHAnalgesics/administration & dosage*-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHEndoscopy*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain, Postoperative/drug therapy-
dc.subject.MESHPain, Postoperative/prevention & control*-
dc.subject.MESHPerioperative Care*-
dc.subject.MESHPostoperative Nausea and Vomiting/drug therapy-
dc.subject.MESHPregabalin-
dc.subject.MESHRobotics*-
dc.subject.MESHThyroid Neoplasms/surgery*-
dc.subject.MESHThyroidectomy*-
dc.subject.MESHYoung Adult-
dc.subject.MESHgamma-Aminobutyric Acid/administration & dosage-
dc.subject.MESHgamma-Aminobutyric Acid/analogs & derivatives*-
dc.titlePerioperative administration of pregabalin for pain after robot-assisted endoscopic thyroidectomy: a randomized clinical trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorJong Ju Jeong-
dc.contributor.googleauthorWoong Youn Chung-
dc.contributor.googleauthorHyun Joo Kim-
dc.contributor.googleauthorKee-Hyun Nam-
dc.contributor.googleauthorYon Hee Shim-
dc.identifier.doi10.1007/s00464-010-1045-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02196-
dc.contributor.localIdA03674-
dc.contributor.localIdA03722-
dc.contributor.localIdA01245-
dc.contributor.localIdA00616-
dc.contributor.localIdA05604-
dc.relation.journalcodeJ02703-
dc.identifier.eissn1432-2218-
dc.identifier.pmid20376496-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00464-010-1045-7-
dc.contributor.alternativeNameShim, Yon Hee-
dc.contributor.alternativeNameChung, Woung Youn-
dc.contributor.alternativeNameJeong, Jong Ju-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameKim, Hyun Zu-
dc.contributor.alternativeNameNam, Kee Hyun-
dc.contributor.affiliatedAuthorShim, Yon Hee-
dc.contributor.affiliatedAuthorChung, Woung Youn-
dc.contributor.affiliatedAuthorJeong, Jong Ju-
dc.contributor.affiliatedAuthorNam, Kee Hyun-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.contributor.affiliatedAuthorKim, Hyun Joo-
dc.citation.volume24-
dc.citation.number11-
dc.citation.startPage2776-
dc.citation.endPage2781-
dc.identifier.bibliographicCitationSURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol.24(11) : 2776-2781, 2010-
dc.identifier.rimsid50003-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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