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Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report

 Jong-Hyun Kim  ;  Yuran Kim  ;  Su-Jung Shin  ;  Jeong-Won Park  ;  Il-Young Jung 
 JOURNAL OF ENDODONTICS, Vol.36(6) : 1086-1091, 2010 
Journal Title
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Acrylic Resins/chemistry ; Anti-Bacterial Agents/adverse effects* ; Anti-Infective Agents/therapeutic use ; Child ; Ciprofloxacin/therapeutic use ; Colorimetry ; Dental Disinfectants/adverse effects ; Dental Pulp Necrosis/drug therapy ; Dental Pulp Necrosis/therapy ; Dentin-Bonding Agents/chemistry ; Drug Combinations ; Female ; Follow-Up Studies ; Humans ; Incisor/drug effects* ; Metronidazole/therapeutic use ; Minocycline/adverse effects ; Periapical Periodontitis/drug therapy ; Periapical Periodontitis/therapy ; Root Canal Irrigants/adverse effects* ; Tooth Bleaching/methods ; Tooth Crown/drug effects ; Tooth Discoloration/chemically induced* ; Tooth Discoloration/prevention & control
INTRODUCTION: A triple antibiotic mixture of ciprofloxacin, metronidazole, and minocycline was used as an intracanal medicament in an attempt to disinfect the root canal system for revascularization of a tooth with a necrotic pulp. However, discoloration developed after applying the triple antibiotic mixture. METHODS: Six weeks after a triple antibiotic paste had been applied to the root canal of tooth #8 of a 7-year-old girl, the tooth showed a dark discoloration. An in vitro experiment with human extracted teeth was performed to determine which of the 3 antibiotics caused the tooth discoloration. Another experiment was then carried out to examine whether a currently used dentin bonding agent would prevent or reduce such discoloration. The degree of discoloration was assessed by using a colorimeter. RESULTS: Among the components of the triple antibiotic paste, only minocycline caused the tooth discoloration. Moreover, the dentin bonding agent reduced the intensity of the discoloration but did not prevent it. CONCLUSIONS: The possible esthetic problems with the tooth color should be considered when using minocycline as a canal medication.
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2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jeong Won(박정원) ORCID logo https://orcid.org/0000-0002-2517-8150
Shin, Su Jung(신수정) ORCID logo https://orcid.org/0000-0001-5795-3919
Jung, Il Young(정일영) ORCID logo https://orcid.org/0000-0001-8972-2664
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