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Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia.

Authors
 Soo-Mee Bang  ;  Ji-Weon Seo  ;  Kyung Un Park  ;  Seok Jin Kim  ;  Kihyun Kim  ;  Sun-Hee Kim  ;  Sung Ran Cho  ;  Hugh C. Kim  ;  Jaewoo Song  ;  Jin Seok Kim  ;  Kyung Hee Kim  ;  Jae Hoon Lee  ;  Je-Jung Lee  ;  Myung Geun Shin  ;  Cheolwon Suh  ;  Hyun Sook Chi  ;  Do-yeun Ohi  ;  Jong-Ho Won  ;  Hyo Jung Kim  ;  Sung-Soo Yoon  ;  Dong Soon Lee 
Citation
 CANCER GENETICS AND CYTOGENETICS , Vol.197(2) : 117-121, 2010 
Journal Title
 CANCER GENETICS AND CYTOGENETICS 
ISSN
 0165-4608 
Issue Date
2010
MeSH
Adult ; Aged ; Aged, 80 and over ; Bone Marrow Cells/pathology ; Chromosome Aberrations* ; Chromosomes, Human, Pair 6 ; Cohort Studies ; Female ; Gene Deletion ; Humans ; Immunoglobulin Heavy Chains/genetics ; In Situ Hybridization, Fluorescence/methods ; Karyotyping ; Korea ; Male ; Middle Aged ; Multiple Myeloma/genetics ; Waldenstrom Macroglobulinemia/genetics* ; Waldenstrom Macroglobulinemia/pathology
Abstract
To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4
Full Text
http://www.sciencedirect.com/science/article/pii/S0165460809006608
DOI
10.1016/j.cancergencyto.2009.11.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/102152
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