1 217

Cited 9 times in

Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia.

DC FieldValueLanguage
dc.contributor.author김진석-
dc.contributor.author송재우-
dc.date.accessioned2015-04-23T17:16:30Z-
dc.date.available2015-04-23T17:16:30Z-
dc.date.issued2010-
dc.identifier.issn0165-4608-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/102152-
dc.description.abstractTo compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4-
dc.description.statementOfResponsibilityopen-
dc.format.extent117~121-
dc.relation.isPartOfCANCER GENETICS AND CYTOGENETICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBone Marrow Cells/pathology-
dc.subject.MESHChromosome Aberrations*-
dc.subject.MESHChromosomes, Human, Pair 6-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHGene Deletion-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin Heavy Chains/genetics-
dc.subject.MESHIn Situ Hybridization, Fluorescence/methods-
dc.subject.MESHKaryotyping-
dc.subject.MESHKorea-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultiple Myeloma/genetics-
dc.subject.MESHWaldenstrom Macroglobulinemia/genetics*-
dc.subject.MESHWaldenstrom Macroglobulinemia/pathology-
dc.titleMolecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorSoo-Mee Bang-
dc.contributor.googleauthorJi-Weon Seo-
dc.contributor.googleauthorKyung Un Park-
dc.contributor.googleauthorSeok Jin Kim-
dc.contributor.googleauthorKihyun Kim-
dc.contributor.googleauthorSun-Hee Kim-
dc.contributor.googleauthorSung Ran Cho-
dc.contributor.googleauthorHugh C. Kim-
dc.contributor.googleauthorJaewoo Song-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorKyung Hee Kim-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorJe-Jung Lee-
dc.contributor.googleauthorMyung Geun Shin-
dc.contributor.googleauthorCheolwon Suh-
dc.contributor.googleauthorHyun Sook Chi-
dc.contributor.googleauthorDo-yeun Ohi-
dc.contributor.googleauthorJong-Ho Won-
dc.contributor.googleauthorHyo Jung Kim-
dc.contributor.googleauthorSung-Soo Yoon-
dc.contributor.googleauthorDong Soon Lee-
dc.identifier.doi10.1016/j.cancergencyto.2009.11.008-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01017-
dc.contributor.localIdA02054-
dc.relation.journalcodeJ00443-
dc.identifier.eissn1873-4456-
dc.identifier.pmid20193844-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0165460809006608-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameSong, Jae Woo-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorSong, Jae Woo-
dc.citation.volume197-
dc.citation.number2-
dc.citation.startPage117-
dc.citation.endPage121-
dc.identifier.bibliographicCitationCANCER GENETICS AND CYTOGENETICS , Vol.197(2) : 117-121, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.