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Effects of Oral Adsorbent AST-120 (Kremezin®) on the Progression of Chronic Kidney Disease

 Yong Kyu Lee  ;  Sung Jin Moon  ;  Hye Rim An  ;  Jwa Kyung Kim  ;  Sung Chang Bae  ;  Beom Seok Kim  ;  Hyeong Cheon Park  ;  Sung Kyu Ha 
 Korean Journal of Nephrology, Vol.29(4) : 450-457, 2010 
Journal Title
Korean Journal of Nephrology
Issue Date
AST-120 ; Chronic renal failure ; Glomerular filtration rate
Purpose: AST-120 is known to delay progression of chronic kidney disease (CKD) when combined
with other proven therapy. AST-120 is an oral adsorbent for uremic toxin, such as indoxyl sulfate from
the gastrointestinal tract. There have been a lot of studies to show its effect in other countries, but
there are few studies done in Korea yet.
Methods: 195 patients were included in the study (mean age, 64±14 years; diabetes mellitus (DM),
104 patients; male, 130 patients). The patients with CKD who started AST-120 and maintained the
medication for at least 6 months were enrolled. The patients’ laboratory results for 6 months before
and after administrating AST-120 was surveyed. Then the rate of patients’ renal functional deterioration
was compared before and after AST-120. In addition, adverse effects during the medication were
Results: There were no statistically significant differences in laboratory data between before and after
AST-120 administration. But, after administrating AST-120, the renal deterioration slope has blunted
significantly from -0.0123±0.0318 to -0.0013±0.0184 dL/mg/month (p<0.01) in 1/sCr and from -1.1423±
2.3906 to 0.0639±1.3825 ml/min/1.73m2/month (p<0.01) in estimated glomerular filtration rate (eGFR).
There were no differences between DM and non-DM patients in the effect of AST-120, as well as
ages over 70 and below 70. There were no serious adverse effects during medication.
Conclusion: This study showed that AST-120 had additive effect on retarding the CKD progression
when combined with established therapy regardless of DM and ages without serious adverse effects.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
Kim, Jwa Kyung(김좌경)
Moon, Sung Jin(문성진)
Park, Hyeong Cheon(박형천) ORCID logo https://orcid.org/0000-0002-1550-0812
Lee, Yong Kyu(이용규)
Ha, Sung Kyu(하성규)
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