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Effects of Oral Adsorbent AST-120 (Kremezin®) on the Progression of Chronic Kidney Disease
DC Field | Value | Language |
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dc.contributor.author | 박형천 | - |
dc.contributor.author | 이용규 | - |
dc.contributor.author | 하성규 | - |
dc.contributor.author | 김범석 | - |
dc.contributor.author | 김좌경 | - |
dc.contributor.author | 문성진 | - |
dc.date.accessioned | 2015-04-23T17:13:31Z | - |
dc.date.available | 2015-04-23T17:13:31Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1975-9460 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/102059 | - |
dc.description.abstract | Purpose: AST-120 is known to delay progression of chronic kidney disease (CKD) when combined with other proven therapy. AST-120 is an oral adsorbent for uremic toxin, such as indoxyl sulfate from the gastrointestinal tract. There have been a lot of studies to show its effect in other countries, but there are few studies done in Korea yet. Methods: 195 patients were included in the study (mean age, 64±14 years; diabetes mellitus (DM), 104 patients; male, 130 patients). The patients with CKD who started AST-120 and maintained the medication for at least 6 months were enrolled. The patients’ laboratory results for 6 months before and after administrating AST-120 was surveyed. Then the rate of patients’ renal functional deterioration was compared before and after AST-120. In addition, adverse effects during the medication were surveyed. Results: There were no statistically significant differences in laboratory data between before and after AST-120 administration. But, after administrating AST-120, the renal deterioration slope has blunted significantly from -0.0123±0.0318 to -0.0013±0.0184 dL/mg/month (p<0.01) in 1/sCr and from -1.1423± 2.3906 to 0.0639±1.3825 ml/min/1.73m2/month (p<0.01) in estimated glomerular filtration rate (eGFR). There were no differences between DM and non-DM patients in the effect of AST-120, as well as ages over 70 and below 70. There were no serious adverse effects during medication. Conclusion: This study showed that AST-120 had additive effect on retarding the CKD progression when combined with established therapy regardless of DM and ages without serious adverse effects. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 450~457 | - |
dc.relation.isPartOf | Korean Journal of Nephrology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of Oral Adsorbent AST-120 (Kremezin®) on the Progression of Chronic Kidney Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yong Kyu Lee | - |
dc.contributor.googleauthor | Sung Jin Moon | - |
dc.contributor.googleauthor | Hye Rim An | - |
dc.contributor.googleauthor | Jwa Kyung Kim | - |
dc.contributor.googleauthor | Sung Chang Bae | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Hyeong Cheon Park | - |
dc.contributor.googleauthor | Sung Kyu Ha | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01759 | - |
dc.contributor.localId | A02975 | - |
dc.contributor.localId | A04252 | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A00931 | - |
dc.contributor.localId | A01364 | - |
dc.relation.journalcode | J02065 | - |
dc.subject.keyword | AST-120 | - |
dc.subject.keyword | Chronic renal failure | - |
dc.subject.keyword | Glomerular filtration rate | - |
dc.contributor.alternativeName | Park, Hyeong Cheon | - |
dc.contributor.alternativeName | Lee, Yong Kyu | - |
dc.contributor.alternativeName | Ha, Sung Kyu | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.alternativeName | Kim, Jwa Kyung | - |
dc.contributor.alternativeName | Moon, Sung Jin | - |
dc.contributor.affiliatedAuthor | Park, Hyeong Cheon | - |
dc.contributor.affiliatedAuthor | Lee, Yong Kyu | - |
dc.contributor.affiliatedAuthor | Ha, Sung Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | Kim, Jwa Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Sung Jin | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 450 | - |
dc.citation.endPage | 457 | - |
dc.identifier.bibliographicCitation | Korean Journal of Nephrology, Vol.29(4) : 450-457, 2010 | - |
dc.identifier.rimsid | 52695 | - |
dc.type.rims | ART | - |
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