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Clinical findings and treatments of granular corneal dystrophy type 2 (avellino corneal dystrophy): a review of the literature

Authors
 Han, Kyung Eun  ;  Kim, Tae-im  ;  Chung, Woo Suk  ;  Choi, Seung-il  ;  Kim, Bong-yoon  ;  Kim, Eung Kweon 
Citation
 EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE, Vol.36(5) : 296-299, 2010 
Journal Title
 EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE 
ISSN
 1542-2321 
Issue Date
2010
MeSH
Chromosomes, Human, Pair 5 ; Contraindications ; Cornea/surgery ; Corneal Dystrophies, Hereditary/genetics* ; Corneal Dystrophies, Hereditary/pathology ; Corneal Dystrophies, Hereditary/surgery* ; Corneal Transplantation ; Extracellular Matrix Proteins/genetics* ; Humans ; Keratomileusis, Laser In Situ ; Lens Implantation, Intraocular ; Mitomycin/therapeutic use ; Mutation* ; Phacoemulsification ; Photorefractive Keratectomy/adverse effects ; Postoperative Complications/prevention & control ; Recurrence ; Refractive Surgical Procedures*/adverse effects ; Transforming Growth Factor beta/genetics*
Keywords
Granular corneal dystrophy type 2 ; Avellino corneal dystrophy ; Surface ablation ; Exacerbation
Abstract
OBJECTIVES: To review the literature about clinical findings and treatments of granular corneal dystrophy type 2 (GCD2). METHODS: Various literatures on clinical findings, exacerbations after refractive corneal surgery, and treatment modalities of GCD2 were reviewed. RESULTS: GCD2 is an autosomal dominant disease. Mutation of transforming growth factor beta-induced gene, TGFBI, or keratoepithelin gene in human chromosome 5 (5q31) is the key pathogenic process in patient with GCD2. Corneal trauma activates TGFBI and then it overproduces transforming growth factor beta-induced gene protein (TGFBIp), which is main component of the corneal opacity. Refractive corneal surgery is a popular procedure to correct refractive error worldwide. However, several cases about exacerbation of GCD2 after corneal refractive surgery such as photorefractive keratectomy, laser in situ keratomileusis, and laser epithelial keratomileusis have been reported. The opacities deteriorate patient's best-corrected visual acuity. Recurrence-free interval varies many factors such as the type of procedure the patient had received and the genotype of the patient. To treat the opacities in GCD2, phototherapeutic keratectomy, lamellar keratoplasty, deep lamellar keratoplasty, and penetrating keratoplasty (PKP) were used. However, the recurrence is still an unsolved problem. CONCLUSIONS: Perfect treatment of exacerbation after corneal surface ablation does not exist until now. To prevent exacerbation, refractive surgeons must do a careful preoperative examination of candidates in refractive surgeries.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00140068-201009000-00013&LSLINK=80&D=ovft
DOI
10.1097/ICL.0b013e3181ef0da0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Corneal Dystrophy Research Institute (각막이상증연구소) > 1. Journal Papers
Yonsei Authors
Kim, Bong Yoon(김봉윤)
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Choi, Seung Il(최승일) ORCID logo https://orcid.org/0000-0001-7168-8795
Han, Kyung Eun(한경은)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101993
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