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Heterogeneous virulence potential and high antibiotic resistance of Pseudomonas aeruginosa strains isolated from Korean pneumonia patients

Authors
 Mi Young Yoon  ;  Kang-Mu Lee  ;  Seok Hoon Jeong  ;  Jungmin Kim  ;  Sang Sun Yoon 
Citation
 JOURNAL OF MICROBIOLOGY, Vol.48(4) : 518-525, 2010 
Journal Title
 JOURNAL OF MICROBIOLOGY 
ISSN
 1225-8873 
Issue Date
2010
MeSH
Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/pharmacology* ; Biofilms ; Child, Preschool ; Drug Resistance, Bacterial* ; Female ; Humans ; Infant ; Male ; Middle Aged ; Pancreatic Elastase/genetics ; Pancreatic Elastase/metabolism ; Phylogeny ; Plasminogen Activator Inhibitor 1/genetics ; Plasminogen Activator Inhibitor 1/metabolism ; Pneumonia/microbiology* ; Pseudomonas Infections/microbiology* ; Pseudomonas aeruginosa/classification ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/isolation & purification ; Pseudomonas aeruginosa/pathogenicity* ; Republic of Korea ; Virulence ; Virulence Factors/genetics ; Virulence Factors/metabolism
Keywords
P. aeruginosa ; virulence ; pneumonia ; biofilm ; quorum sensing
Abstract
Pseudomonas aeruginosa is an opportunistic human pathogen of clinical importance that causes airway infections in immunocompromised patients. Here, we report the virulence-associated characteristics of strains of P. aeruginosa, isolated from the sputa of 25 Korean pneumonia patients. A high degree of genomic plasticity was observed by random amplified polymorphic DNA genotype analysis, suggesting that the infections were caused by strains with diverse genomic backgrounds. Biofilm formation of each isolate was heterogeneous in terms of their relative motilities. In addition, 48% of isolates were defective in the production of 3-oxo-C(12)-HSL (PAI-1), a quorum sensing signal molecule. In these strains, PAI-1-dependent elastase production was correspondingly decreased, suggesting that a large number of strains were presumed to be quorum sensing deficient. Multidrug resistance (MDR) was seen in 56% of the isolates tested, and 44% of the MDR strains were resistant to five or more antibiotics. Taken together, our results provide additional insights into the virulence traits of P. aeruginosa clinical isolates, which will aid in treating P. aeruginosa infections in pneumonia patients.
Full Text
http://link.springer.com/article/10.1007%2Fs12275-010-9388-2
DOI
10.1007/s12275-010-9388-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101935
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