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Heterogeneous virulence potential and high antibiotic resistance of Pseudomonas aeruginosa strains isolated from Korean pneumonia patients

DC FieldValueLanguage
dc.contributor.author정석훈-
dc.contributor.author윤상선-
dc.date.accessioned2015-04-23T17:09:39Z-
dc.date.available2015-04-23T17:09:39Z-
dc.date.issued2010-
dc.identifier.issn1225-8873-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101935-
dc.description.abstractPseudomonas aeruginosa is an opportunistic human pathogen of clinical importance that causes airway infections in immunocompromised patients. Here, we report the virulence-associated characteristics of strains of P. aeruginosa, isolated from the sputa of 25 Korean pneumonia patients. A high degree of genomic plasticity was observed by random amplified polymorphic DNA genotype analysis, suggesting that the infections were caused by strains with diverse genomic backgrounds. Biofilm formation of each isolate was heterogeneous in terms of their relative motilities. In addition, 48% of isolates were defective in the production of 3-oxo-C(12)-HSL (PAI-1), a quorum sensing signal molecule. In these strains, PAI-1-dependent elastase production was correspondingly decreased, suggesting that a large number of strains were presumed to be quorum sensing deficient. Multidrug resistance (MDR) was seen in 56% of the isolates tested, and 44% of the MDR strains were resistant to five or more antibiotics. Taken together, our results provide additional insights into the virulence traits of P. aeruginosa clinical isolates, which will aid in treating P. aeruginosa infections in pneumonia patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent518~525-
dc.relation.isPartOfJOURNAL OF MICROBIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHBiofilms-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDrug Resistance, Bacterial*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPancreatic Elastase/genetics-
dc.subject.MESHPancreatic Elastase/metabolism-
dc.subject.MESHPhylogeny-
dc.subject.MESHPlasminogen Activator Inhibitor 1/genetics-
dc.subject.MESHPlasminogen Activator Inhibitor 1/metabolism-
dc.subject.MESHPneumonia/microbiology*-
dc.subject.MESHPseudomonas Infections/microbiology*-
dc.subject.MESHPseudomonas aeruginosa/classification-
dc.subject.MESHPseudomonas aeruginosa/genetics-
dc.subject.MESHPseudomonas aeruginosa/isolation & purification-
dc.subject.MESHPseudomonas aeruginosa/pathogenicity*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHVirulence-
dc.subject.MESHVirulence Factors/genetics-
dc.subject.MESHVirulence Factors/metabolism-
dc.titleHeterogeneous virulence potential and high antibiotic resistance of Pseudomonas aeruginosa strains isolated from Korean pneumonia patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorMi Young Yoon-
dc.contributor.googleauthorKang-Mu Lee-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorJungmin Kim-
dc.contributor.googleauthorSang Sun Yoon-
dc.identifier.doi10.1007/s12275-010-9388-2-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03619-
dc.contributor.localIdA02558-
dc.relation.journalcodeJ01593-
dc.identifier.eissn1976-3794-
dc.identifier.pmid20799095-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs12275-010-9388-2-
dc.subject.keywordP. aeruginosa-
dc.subject.keywordvirulence-
dc.subject.keywordpneumonia-
dc.subject.keywordbiofilm-
dc.subject.keywordquorum sensing-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.alternativeNameYoon, Sang Sun-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.contributor.affiliatedAuthorYoon, Sang Sun-
dc.citation.volume48-
dc.citation.number4-
dc.citation.startPage518-
dc.citation.endPage525-
dc.identifier.bibliographicCitationJOURNAL OF MICROBIOLOGY, Vol.48(4) : 518-525, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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