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Assessment of tissue characteristics of noncalcified coronary plaques by 64-slice computed tomography in comparison with integrated backscatter intravascular ultrasound

 Woo-In Yang  ;  Jin Hur  ;  Young-Guk Ko  ;  Byung-Wook Choi  ;  Jung-Sun Kim  ;  Donghoon Choi  ;  Jong-Won Ha  ;  Meonong-Ki Hong  ;  Yangsoo Jang  ;  Namsik Chung  ;  Won-Heum Shim  ;  Seung-Yun Cho 
 CORONARY ARTERY DISEASE, Vol.21(3) : 168-174, 2010 
Journal Title
Issue Date
Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/etiology ; Adult ; Aged ; Angina Pectoris/diagnostic imaging ; Angina Pectoris/etiology ; Angina, Unstable/diagnostic imaging ; Angina, Unstable/etiology ; Calcinosis/diagnostic imaging ; Chi-Square Distribution ; Coronary Angiography/methods* ; Coronary Stenosis/complications ; Coronary Stenosis/diagnostic imaging* ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Severity of Illness Index ; Tomography, X-Ray Computed* ; Ultrasonography, Interventional*
BACKGROUND: The ability of 64-slice computed tomography (CT) angiography to differentiate plaque types remains unclear. We evaluated whether the density of noncalcified coronary plaques by 64-slice CT angiography correlates with plaque components assessed by integrated backscatter intravascular ultrasound (IB-IVUS). METHODS: Eighty-six patients [stable angina/acute coronary syndrome (ACS) 67/19, mean age 62+/-11 years] who showed significant coronary artery stenosis (> or =50% diameter stenosis) by 64-slice CT angiography underwent coronary angiography and were evaluated using IB-IVUS. RESULTS: A total of 92 noncalcified coronary plaques on CT angiography were evaluated with IB-IVUS. There was a positive correlation between CT density and calcified tissue content (r=0.41, P<0.001). However, the CT density of plaques did not correlate with other tissue components. Patients with ACS showed more lipid (43.1+/-13.2 vs. 35.8+/-13.5, P=0.03) and less soft fibrous tissue (50.5+/-11.7 vs. 56.5+/-12.0, P=0.05) by IB-IVUS than those with stable angina. However, the mean CT density of plaques in ACS was not different from that in stable angina (140.6+/-88.5 vs. 113.1+/-80.9, P=0.19). CONCLUSION: Except for calcified tissue, CT angiography failed to differentiate plaque types of noncalcified tissue. Therefore, the role of 64-slice CT angiography in identifying lipid-rich plaques remains limited.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Ko, Young Guk(고영국) ORCID logo https://orcid.org/0000-0001-7748-5788
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shim, Won Heum(심원흠)
Yang, Woo In(양우인)
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Cho, Seung Yun(조승연)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
Hur, Jin(허진) ORCID logo https://orcid.org/0000-0002-8651-6571
Hong, Myeong Ki(홍명기) ORCID logo https://orcid.org/0000-0002-2090-2031
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