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Osteoconductive effects of calcium phosphate glass cement grafts in rabbit calvarial defects

Authors
 Hyun-Chang Lim  ;  Joo-Yeon Sohn  ;  Jung-Chul Park  ;  Yoo-Jung Um  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Yong-Keun Lee  ;  Seong-Ho Choi 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol.95(1) : 47-52, 2010 
Journal Title
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 
ISSN
 1552-4973 
Issue Date
2010
MeSH
Animals ; Bone Regeneration/drug effects* ; Bone Resorption ; Bone Substitutes/chemistry* ; Bone Substitutes/pharmacology ; Calcium Phosphates/pharmacology* ; Glass ; Kinetics ; Osteogenesis ; Rabbits ; Skull/injuries*
Keywords
bone graft ; calcium phosphate ;   ; scaffolds ; biocompatibility/hard tissue ; dental/craniofacial material
Abstract
Calcium phosphate glass (CPG) is well-documented alloplastic bone graft material. The objective of this study was to evaluate the osteoconductive effect of newly developed calcium phosphate glass cement (CPGC) in rabbit calvarial defects. Three circular defects (8 mm diameter) were created on the rabbit calvarium. One defect was filled with biphasic calcium phosphate (BCP group) and one defect was filled with CPGC (CPGC group). The remaining defect was not filled as the control. Histologic and histometric analysis were performed at four and eight weeks following the implantation of materials. One-way ANOVA method was used to evaluated the significance between three groups (p < 0.05). The CPGC group did not show a statistical difference in new bone area compared with the control at all healing periods, but the bone formation rate of CPGC seemed to increase between four and eight weeks. This suggests the bone formation rate of CPGC is initially slow, but increases at a specific time, showing the possibility of greater bone formation with time. The resorption rate of CPGC was greater than BCP. Within the limits of this study, CPGC demonstrated good space maintaining capacity and had an osteoconductive effect, suggesting it could be successfully used to improve bone formation capacity.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31681/abstract
DOI
10.1002/jbm.b.31681
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Park, Jung Chul(박정철)
Um, Yoo Jung(엄유정)
Lee, Yong Keun(이용근)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101809
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