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Computed tomographic fluoroscopy-guided needle aspiration biopsy as a second biopsy technique after indeterminate transbronchial biopsy results for pulmonary lesions: comparison with second transbronchial biopsy

 Jin Hur  ;  Hye-Jeong Lee  ;  Min Kwang Byun  ;  Ji Eun Nam  ;  Jin Wook Moon  ;  Hua Sun Kim  ;  Young Jin Kim  ;  Kyu Ok Choe  ;  Byoung Wook Choi 
 Journal of Computer Assisted Tomography, Vol.34(2) : 290-295, 2010 
Journal Title
 Journal of Computer Assisted Tomography 
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biopsy, Needle/methods* ; Bronchoscopy ; Diagnosis, Differential ; Female ; Fluoroscopy ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology* ; Male ; Middle Aged ; Radiography, Interventional* ; Sensitivity and Specificity ; Tomography, X-Ray Computed*
computed tomography (CT) ; fluoroscopy ; bronchoscopy ; biopsy
OBJECTIVE: The purpose of this study was to compare the diagnostic performance of computed tomographic (CT) fluoroscopy-guided percutaneous transthoracic needle aspiration biopsy (NAB) and transbronchial lung biopsy (TBLB) after indeterminate bronchoscopy in patients with suspected malignant pulmonary lesions. METHODS: We included 77 patients who underwent CTF-NAB (n = 53) or TBLB (n = 24) as a second biopsy for pulmonary lesions because of inconclusive pathologic results on initial TBLB. Sensitivity, specificity, and diagnostic accuracy were calculated and compared between the 2 groups using the Fisher exact test. Sensitivity and diagnostic accuracy were also compared according to lesion depth (central vs peripheral), lesion location (upper vs lower), and lesion size (<2 vs 2-3 vs >3 cm). RESULTS: There were 50 (65%) malignant and 27 (35%) benign lesions. The overall sensitivity, specificity, and accuracy for diagnosing pulmonary lesions were 84%, 100%, and 91% for NAB and 50%, 100%, and 63% for TBLB. The sensitivity and accuracy for diagnosing pulmonary lesions were significantly different between the 2 groups (P = 0.019, and P = 0.008). The sensitivity and accuracy of TBLB for diagnosing lesions was significantly different according to the lesion size (P = 0.025, and P = 0.048). CONCLUSION: A second biopsy using CT fluoroscopy-guided NAB is a useful diagnostic modality for exact diagnosis of pulmonary lesions in cases of inconclusive pathologic results on initial TBLB.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Jin(김영진) ORCID logo https://orcid.org/0000-0002-6235-6550
Kim, Hua Sun(김화선)
Nam, Ji Eun(남지은)
Moon, Jin Wook(문진욱)
Byun, Min Kwang(변민광) ORCID logo https://orcid.org/0000-0003-1525-1745
Lee, Hye Jeong(이혜정) ORCID logo https://orcid.org/0000-0003-4349-9174
Choe, Kyu Ok(최규옥)
Choi, Byoung Wook(최병욱) ORCID logo https://orcid.org/0000-0002-8873-5444
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