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Anterior pituitary dysfunction in moderate-to-severe chronic traumatic brain injury patients and the influence on functional outcome.

 Ki Deok Park  ;  Deog Young Kim  ;  Ju Kang Lee  ;  Hee-Seung Nam  ;  Yoon-Ghil Park 
 Brain Injury, Vol.24(11) : 1330-1335, 2010 
Journal Title
 Brain Injury 
Issue Date
Adult ; Body Mass Index ; Brain Injuries/physiopathology* ; Brain Injuries/rehabilitation ; Chronic Disease ; Female ; Humans ; Hypopituitarism/physiopathology* ; Hypopituitarism/rehabilitation ; Male ; Pituitary Gland, Anterior/metabolism ; Pituitary Gland, Anterior/physiopathology* ; Pituitary Hormones, Anterior/deficiency ; Pituitary Hormones, Anterior/metabolism*
Traumatic brain injury ; pituitary dysfunction ; BMI ; functional outcome
OBJECTIVE: The objective of this study is to determine the prevalence of anterior pituitary dysfunction in moderate-to-severe chronic traumatic brain injury (TBI) patients. The investigation of a relationship between pituitary hormonal status and body mass index (BMI) in TBI patients by observing changes in BMI was conducted as well as an assessment of whether there is a difference in functional outcome related to anterior pituitary dysfunction in TBI patients. METHODS: Forty-five TBI patients and 30 normal controls underwent a series of standard endocrine tests for anterior pituitary hormone function. It was studied whether changes in BMI correlated with anterior pituitary hormone levels. This study also compared changes in mini-mental state examination (K-MMSE) and functional independence measure (FIM) scores between patients in the hormone-sufficient and -deficient groups. RESULTS: Anterior pituitary dysfunction was found in 31.1% of TBI patients. Changes in BMI statistically correlated with IGF-1 and basal cortisol levels. A meaningful difference was found between the hormone-sufficient and -deficient groups in light of the K-MMSE and FIM score gains. CONCLUSIONS: These findings strongly suggest that patients who suffer head trauma should be routinely tested for anterior pituitary hormone deficiency.
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1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Deog Young(김덕용) ORCID logo https://orcid.org/0000-0001-7622-6311
Park, Yoon Ghil(박윤길) ORCID logo https://orcid.org/0000-0001-9054-5300
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