1 334

Cited 12 times in

Increased serum B cell-activating factor level in children with atopic dermatitis.

Authors
 H. M. Jee  ;  K. W. Kim  ;  J. Y. Hong  ;  M. H. Sohn  ;  K. E. Kim 
Citation
 CLINICAL AND EXPERIMENTAL DERMATOLOGY, Vol.35(6) : 593-598, 2010 
Journal Title
 CLINICAL AND EXPERIMENTAL DERMATOLOGY 
ISSN
 0307-6938 
Issue Date
2010
MeSH
Adolescent ; Analysis of Variance ; B-Cell Activating Factor/blood* ; Biomarkers/blood ; Case-Control Studies ; Child ; Child, Preschool ; Dermatitis, Atopic/blood* ; Female ; Humans ; Infant ; Male ; Severity of Illness Index
Abstract
BACKGROUND: B cell-activating factor (BAFF) is a tumour necrosis factor superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is seen in naïve and effector/memory T cells. AIM: To investigate the level and role of BAFF in serum of patients with atopic dermatitis (AD). METHODS: Levels of serum BAFF, a proliferation-inducing ligand (APRIL) and total serum IgE level, and total eosinophil count were measured in 245 children. RESULTS: Patients were characterized as having atopic eczema (AE) (n = 90) or non-AE (n = 77); the remainder were healthy control subjects (n = 78). Serum BAFF level in children with AE (1625.04 +/- 708.32 pg/mL) was significantly higher than in non-AE children (1194.69 +/- 448.44 pg/mL, P < 0.0001) or healthy controls (1062.89 +/- 444.74 pg/mL, P < 0.0001). Serum APRIL level was not different between the three groups. Serum BAFF level significantly correlated with total serum IgE level (gamma = 0.42, P < 0.0001) and total eosinophil count. It was also positively correlated with serum BAFF and egg-specific IgE level (gamma = 0.252, P = 0.045) in AE. CONCLUSIONS: Serum BAFF level is high in AE and might be a useful marker for AE.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2230.2009.03635.x/abstract
DOI
10.1111/j.1365-2230.2009.03635.x
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Jee, Hye Mi(지혜미)
Hong, Jung Yeon(홍정연) ORCID logo https://orcid.org/0000-0003-0406-9956
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101625
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links