Cited 14 times in
Increased serum B cell-activating factor level in children with atopic dermatitis.
DC Field | Value | Language |
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dc.contributor.author | 김경원 | - |
dc.contributor.author | 김규언 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 홍정연 | - |
dc.date.accessioned | 2015-04-23T16:59:42Z | - |
dc.date.available | 2015-04-23T16:59:42Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0307-6938 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101625 | - |
dc.description.abstract | BACKGROUND: B cell-activating factor (BAFF) is a tumour necrosis factor superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is seen in naïve and effector/memory T cells. AIM: To investigate the level and role of BAFF in serum of patients with atopic dermatitis (AD). METHODS: Levels of serum BAFF, a proliferation-inducing ligand (APRIL) and total serum IgE level, and total eosinophil count were measured in 245 children. RESULTS: Patients were characterized as having atopic eczema (AE) (n = 90) or non-AE (n = 77); the remainder were healthy control subjects (n = 78). Serum BAFF level in children with AE (1625.04 +/- 708.32 pg/mL) was significantly higher than in non-AE children (1194.69 +/- 448.44 pg/mL, P < 0.0001) or healthy controls (1062.89 +/- 444.74 pg/mL, P < 0.0001). Serum APRIL level was not different between the three groups. Serum BAFF level significantly correlated with total serum IgE level (gamma = 0.42, P < 0.0001) and total eosinophil count. It was also positively correlated with serum BAFF and egg-specific IgE level (gamma = 0.252, P = 0.045) in AE. CONCLUSIONS: Serum BAFF level is high in AE and might be a useful marker for AE. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CLINICAL AND EXPERIMENTAL DERMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | B-Cell Activating Factor/blood* | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Dermatitis, Atopic/blood* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.title | Increased serum B cell-activating factor level in children with atopic dermatitis. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | H. M. Jee | - |
dc.contributor.googleauthor | K. W. Kim | - |
dc.contributor.googleauthor | J. Y. Hong | - |
dc.contributor.googleauthor | M. H. Sohn | - |
dc.contributor.googleauthor | K. E. Kim | - |
dc.identifier.doi | 10.1111/j.1365-2230.2009.03635.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00327 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A03973 | - |
dc.contributor.localId | A04431 | - |
dc.relation.journalcode | J00549 | - |
dc.identifier.eissn | 1365-2230 | - |
dc.identifier.pmid | 19874366 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2230.2009.03635.x/abstract | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.alternativeName | Kim, Kyu Earn | - |
dc.contributor.alternativeName | Son, Myung Hyun | - |
dc.contributor.alternativeName | Hong, Jung Yeon | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Earn | - |
dc.contributor.affiliatedAuthor | Son, Myung Hyun | - |
dc.contributor.affiliatedAuthor | Hong, Jung Yeon | - |
dc.citation.volume | 35 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 593 | - |
dc.citation.endPage | 598 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL DERMATOLOGY, Vol.35(6) : 593-598, 2010 | - |
dc.identifier.rimsid | 40125 | - |
dc.type.rims | ART | - |
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