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Psychotic features as the first manifestation of 22q11.2 deletion syndrome

Authors
 So Dahm Kook  ;  Suk Kyoon An  ;  Kyung Ran Kim  ;  Woo Jung Kim  ;  Eun Lee  ;  Kee Namkoong 
Citation
 PSYCHIATRY INVESTIGATION, Vol.7(1) : 72-74, 2010 
Journal Title
PSYCHIATRY INVESTIGATION
ISSN
 1738-3684 
Issue Date
2010
Keywords
22q11.2 deletion ; Immunodeficiency ; Schizophrenia ; Seizure ; Velocardiofacial syndrome
Abstract
The 22q11.2 deletion is a genetic disorder which is characterized by abnormalities in cardiac functioning, facial structure, neurobehavioral development, T cell functioning, and velopharyngeal insufficiencies. In the presented case study, 22q11.2 deletion was found in a patient who has psychotic symptoms only. A 25-year-old woman with a history of hypoparathyroidism and hypothyroidism presented with auditory hallucinations and persecutory delusions. After three months of treatment with antipsychotic medications, the patient was readmitted with generalized tonic-clonic seizures. The following week, the patient went into sepsis. A fluorescent in situ hybridization (FISH) analysis revealed the presence of a 22q11.2 microdeletion. This case study suggests that psychotic symptoms can develop prior to the typical symptoms of a 22q11.2 deletion. As such, psychiatrists should test for genetic abnormalities in patients with schizophrenia when these patients present with seizures and immunodeficiencies
Files in This Item:
T201002464.pdf Download
DOI
10.4306/pi.2010.7.1.72
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101607
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