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Psychotic features as the first manifestation of 22q11.2 deletion syndrome

Authors
 So Dahm Kook  ;  Suk Kyoon An  ;  Kee Namkoong  ;  Eun Lee  ;  Woo Jung Kim  ;  Kyung Ran Kim 
Citation
 Psychiatry Investigation, Vol.7(1) : 72-74, 2010 
Journal Title
 Psychiatry Investigation 
ISSN
 1738-3684 
Issue Date
2010
Abstract
The 22q11.2 deletion is a genetic disorder which is characterized by abnormalities in cardiac functioning, facial structure, neurobehavioral development, T cell functioning, and velopharyngeal insufficiencies. In the presented case study, 22q11.2 deletion was found in a patient who has psychotic symptoms only. A 25-year-old woman with a history of hypoparathyroidism and hypothyroidism presented with auditory hallucinations and persecutory delusions. After three months of treatment with antipsychotic medications, the patient was readmitted with generalized tonic-clonic seizures. The following week, the patient went into sepsis. A fluorescent in situ hybridization (FISH) analysis revealed the presence of a 22q11.2 microdeletion. This case study suggests that psychotic symptoms can develop prior to the typical symptoms of a 22q11.2 deletion. As such, psychiatrists should test for genetic abnormalities in patients with schizophrenia when these patients present with seizures and immunodeficiencies
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101607
DOI
10.4306/pi.2010.7.1.72
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
김경란(Kim, Kyung Ran) ; 남궁기(Namkoong, Kee) ; 안석균(An, Suk Kyoon) ; 이은(Lee, Eun)
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