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녹차추출물 (-)-Epigallocatechin-3-gallate가 사람치주인대섬유모세포 활성 유지에 미치는 영향

Other Titles
 The Effect of (-)-Epigallocatechin-3-gallate on The Stability of Human Periodontal Ligament Fibroblast viability 
Authors
 정임희  ;  윤정호  ;  정의원  ;  김창성  ;  김남희  ;  정원균  ;  최성호 
Citation
 Biomaterials Research (생체재료학회지), Vol.14(3) : 103-110, 2010 
Journal Title
 Biomaterials Research (생체재료학회지) 
ISSN
 1226-1226 
Issue Date
2010
Keywords
EGCG ; human PDL fibroblast ; viability ; preservation ; MTT
Abstract
The purpose of this study was to evaluate the effect of (-)-Epigallocatechin-3-gallate (EGCG) on the viability of human periodontal ligament fibroblast (hPDLF). Firstly, various concentration of EGCG were applied to hPDLF for 8 days, and then 10 μM EGCG was put for the first 6 days to the experimental group and was stopped for the next 8days. For the positive control group, the 10 μM EGCG was supplied during the whole period, while any EGCG was not supplied for the negative control. Cell viability was analyzed with MTT assay. In the first experiment, the group which treated 10 μM EGCG for 6days showed highest cell viability. In the second treatment, the negative control showed continuous growing up in cell proliferation until 12th day and then a little decreased. After stopping EGCG supply, the experimental group’s proliferation was slightly cut down and then showed big increases. Lastly, the positive control°Øs increase was lasted during the whole period, but there was no a large variance and it showed lowest cell viability on 14th day. From these results, we concluded that EGCG do not affect such a lot on the increase of hPDLF proliferation, but it is possible for EGCG to make hPDLF hibernate with proper concentration of EGCG.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Yun, Jeong Ho(윤정호)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Jung, Im Hee(정임희)
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101545
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