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Increased urinary nerve growth factor as a predictor of persistent detrusor overactivity after bladder outlet obstruction relief in a rat model.

Authors
 Seung Ryeol Lee  ;  Chang Hee Hong  ;  Young Deuk Choi  ;  Jang Hwan Kim 
Citation
 Journal of Urology, Vol.183(6) : 2440-2444, 2010 
Journal Title
 Journal of Urology 
ISSN
 0022-5347 
Issue Date
2010
Abstract
PURPOSE: We evaluated urinary nerve growth factor as a predictive factor for persistent detrusor overactivity after bladder outlet obstruction relief in a rat model. MATERIALS AND METHODS: A total of 50 female Sprague-Dawley(R) rats were divided into 2 groups, including 10 sham operated controls and 40 with bladder outlet obstruction. Obstruction was induced by partial urethral ligation and relieved by ligation removal after 3 weeks. Voided urine was collected before bladder outlet obstruction at time 1, 3 weeks after obstruction onset at time 2 and 3 weeks after obstruction relief at time 3. Cystometry was done in awake rats at times 2 and 3. Bladder tissue was harvested at time 3. Urinary and bladder tissue nerve growth factor was measured by enzyme-linked immunosorbent assay with results adjusted based on creatinine concentration. RESULTS: In 16 rats in which detrusor overactivity disappeared after bladder outlet obstruction relief (group 1) urinary nerve growth factor/creatinine significantly increased from time 1 to 2 and significantly decreased from time 2 to 3 (p = 0.001 and 0.003, respectively). In 8 rats with persistent detrusor overactivity despite obstruction removal (group 2) urinary nerve growth factor/creatinine significantly increased from time 1 to 2 but did not change from time 2 to 3 (p = 0.012 and 0.123, respectively). These rats with persistent detrusor overactivity also had significantly higher urinary nerve growth factor/creatinine at time 1 than controls and group 1 (p = 0.015 and 0.005, respectively). CONCLUSIONS: Changes in urinary nerve growth factor may reflect detrusor overactivity, as diagnosed on 2 consecutive cystometries. Increased urinary nerve growth factor before bladder outlet obstruction may predict persistent detrusor overactivity after obstruction relief
Full Text
http://www.sciencedirect.com/science/article/pii/S0022534710002442
DOI
10.1016/j.juro.2010.02.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
김장환(Kim, Jang Hwan)
이승렬(Lee, Seung Ryeol)
최영득(Choi, Young Deuk) ORCID logo https://orcid.org/0000-0002-8545-5797
홍창희(Hong, Chang Hee) ORCID logo https://orcid.org/0000-0002-0946-7702
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101457
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