Cited 22 times in
Increased urinary nerve growth factor as a predictor of persistent detrusor overactivity after bladder outlet obstruction relief in a rat model.
DC Field | Value | Language |
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dc.contributor.author | 김장환 | - |
dc.contributor.author | 이승렬 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 홍창희 | - |
dc.date.accessioned | 2015-04-23T16:54:31Z | - |
dc.date.available | 2015-04-23T16:54:31Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0022-5347 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101457 | - |
dc.description.abstract | PURPOSE: We evaluated urinary nerve growth factor as a predictive factor for persistent detrusor overactivity after bladder outlet obstruction relief in a rat model. MATERIALS AND METHODS: A total of 50 female Sprague-Dawley(R) rats were divided into 2 groups, including 10 sham operated controls and 40 with bladder outlet obstruction. Obstruction was induced by partial urethral ligation and relieved by ligation removal after 3 weeks. Voided urine was collected before bladder outlet obstruction at time 1, 3 weeks after obstruction onset at time 2 and 3 weeks after obstruction relief at time 3. Cystometry was done in awake rats at times 2 and 3. Bladder tissue was harvested at time 3. Urinary and bladder tissue nerve growth factor was measured by enzyme-linked immunosorbent assay with results adjusted based on creatinine concentration. RESULTS: In 16 rats in which detrusor overactivity disappeared after bladder outlet obstruction relief (group 1) urinary nerve growth factor/creatinine significantly increased from time 1 to 2 and significantly decreased from time 2 to 3 (p = 0.001 and 0.003, respectively). In 8 rats with persistent detrusor overactivity despite obstruction removal (group 2) urinary nerve growth factor/creatinine significantly increased from time 1 to 2 but did not change from time 2 to 3 (p = 0.012 and 0.123, respectively). These rats with persistent detrusor overactivity also had significantly higher urinary nerve growth factor/creatinine at time 1 than controls and group 1 (p = 0.015 and 0.005, respectively). CONCLUSIONS: Changes in urinary nerve growth factor may reflect detrusor overactivity, as diagnosed on 2 consecutive cystometries. Increased urinary nerve growth factor before bladder outlet obstruction may predict persistent detrusor overactivity after obstruction relief | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2440~2444 | - |
dc.relation.isPartOf | JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Muscle, Smooth/physiopathology* | - |
dc.subject.MESH | Nerve Growth Factor/urine* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Urinary Bladder Neck Obstruction/physiopathology* | - |
dc.subject.MESH | Urinary Bladder Neck Obstruction/therapy | - |
dc.subject.MESH | Urinary Bladder Neck Obstruction/urine* | - |
dc.subject.MESH | Urinary Bladder, Overactive/physiopathology* | - |
dc.subject.MESH | Urinary Bladder, Overactive/urine* | - |
dc.title | Increased urinary nerve growth factor as a predictor of persistent detrusor overactivity after bladder outlet obstruction relief in a rat model. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Seung Ryeol Lee | - |
dc.contributor.googleauthor | Chang Hee Hong | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Jang Hwan Kim | - |
dc.identifier.doi | 10.1016/j.juro.2010.02.003 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00855 | - |
dc.contributor.localId | A02915 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04447 | - |
dc.relation.journalcode | J01921 | - |
dc.identifier.eissn | 1527-3792 | - |
dc.identifier.pmid | 20403616 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0022534710002442 | - |
dc.subject.keyword | urinary bladder | - |
dc.subject.keyword | overactive | - |
dc.subject.keyword | urinary bladder neck obstruction | - |
dc.subject.keyword | nerve growth factor | - |
dc.subject.keyword | rats | - |
dc.subject.keyword | Sprague-Dawley | - |
dc.subject.keyword | predictive value of tests | - |
dc.contributor.alternativeName | Kim, Jang Hwan | - |
dc.contributor.alternativeName | Lee, Seung Ryeol | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.alternativeName | Hong, Chang Hee | - |
dc.contributor.affiliatedAuthor | Kim, Jang Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Seung Ryeol | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Hong, Chang Hee | - |
dc.citation.volume | 183 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2440 | - |
dc.citation.endPage | 2444 | - |
dc.identifier.bibliographicCitation | JOURNAL OF UROLOGY, Vol.183(6) : 2440-2444, 2010 | - |
dc.identifier.rimsid | 51070 | - |
dc.type.rims | ART | - |
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