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A comparative study of protein expression in primary colorectal cancer and synchronous hepatic metastases: the significance of matrix metalloproteinase-1 expression as a predictor of liver metastasis

Authors
 Young Wan Kim  ;  Yong Taek Ko  ;  Nam Kyu Kim  ;  Hyun Cheol Chung  ;  Byung Soh Min  ;  Kang Young Lee  ;  Jong-pil Park  ;  Hoguen Kim 
Citation
 SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, Vol.45(2) : 217-225, 2010 
Journal Title
 SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 
ISSN
 0036-5521 
Issue Date
2010
MeSH
Biomarkers, Tumor/metabolism ; Carcinoembryonic Antigen/metabolism ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology* ; Female ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/secondary* ; Male ; Matrix Metalloproteinase 1/metabolism* ; Matrix Metalloproteinase 7/metabolism ; Middle Aged ; Tissue Inhibitor of Metalloproteinases/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Keywords
Colonic neoplasm ; liver metastasis ; protein expression
Abstract
OBJECTIVE: This study was undertaken to determine the ability of protein expression in primary colorectal cancer and metastatic liver tumour tissues to predict hepatic metastasis and intrahepatic recurrence. MATERIAL AND METHODS: Sixty patients with colorectal cancer were enrolled in this study. The expression of the following five proteins was assessed by immunohistochemical (IHC) staining: carcinoembryonic antigen (CEA); vascular endothelial growth factor (VEGF); matrix metalloproteinase (MMP)-1; MMP-7; and tissue inhibitor of metalloproteinases (TIMP)-1. Protein expression was measured in patients with primary colorectal cancer without liver metastasis (Group A), in patients with primary colorectal cancer with liver metastasis (primary tumour; Group B), and in patients with resected metastatic liver tumour tissues (liver metastasis; Group C). RESULTS: IHC staining revealed more protease activity (MMP-1 and -7) in Group B than in Group A. Angiogenic activity (positive VEGF expression) was significantly greater in Group C than in Group B. Multivariate analysis showed that positive MMP-1 expression, the presence of lymphovascular invasion, and an elevated pre-operative serum CEA level (> 5 ng/ml) were significantly related to synchronous liver metastasis. However, intrahepatic recurrence was not related to protein expression, the presence of lymphovascular invasion, or the pre-operative CEA level. CONCLUSIONS: Our findings suggest that protease activity is important for metastasis, and that angiogenic activity is essential for metastatic tumour growth. Furthermore, positive MMP-1 expression in primary colorectal tumour tissues was a significant predictor of liver metastasis. However, the prognostic impact of protein marker expression in terms of intrahepatic recurrence appears to be minimal
Full Text
http://informahealthcare.com/doi/abs/10.3109/00365520903453158
DOI
10.3109/00365520903453158
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Ko, Yong Taek(고용택)
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Young Wan(김영완)
Kim, Hogeun(김호근)
Min, Byung Soh(민병소) ORCID logo https://orcid.org/0000-0003-0180-8565
Park, Jong Pil(박종필) ORCID logo https://orcid.org/0000-0002-6525-3012
Lee, Kang Young(이강영)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101405
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