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A comparative study of protein expression in primary colorectal cancer and synchronous hepatic metastases: the significance of matrix metalloproteinase-1 expression as a predictor of liver metastasis
DC Field | Value | Language |
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dc.contributor.author | 고용택 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김영완 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 민병소 | - |
dc.contributor.author | 박종필 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2015-04-23T16:52:54Z | - |
dc.date.available | 2015-04-23T16:52:54Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0036-5521 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101405 | - |
dc.description.abstract | OBJECTIVE: This study was undertaken to determine the ability of protein expression in primary colorectal cancer and metastatic liver tumour tissues to predict hepatic metastasis and intrahepatic recurrence. MATERIAL AND METHODS: Sixty patients with colorectal cancer were enrolled in this study. The expression of the following five proteins was assessed by immunohistochemical (IHC) staining: carcinoembryonic antigen (CEA); vascular endothelial growth factor (VEGF); matrix metalloproteinase (MMP)-1; MMP-7; and tissue inhibitor of metalloproteinases (TIMP)-1. Protein expression was measured in patients with primary colorectal cancer without liver metastasis (Group A), in patients with primary colorectal cancer with liver metastasis (primary tumour; Group B), and in patients with resected metastatic liver tumour tissues (liver metastasis; Group C). RESULTS: IHC staining revealed more protease activity (MMP-1 and -7) in Group B than in Group A. Angiogenic activity (positive VEGF expression) was significantly greater in Group C than in Group B. Multivariate analysis showed that positive MMP-1 expression, the presence of lymphovascular invasion, and an elevated pre-operative serum CEA level (> 5 ng/ml) were significantly related to synchronous liver metastasis. However, intrahepatic recurrence was not related to protein expression, the presence of lymphovascular invasion, or the pre-operative CEA level. CONCLUSIONS: Our findings suggest that protease activity is important for metastasis, and that angiogenic activity is essential for metastatic tumour growth. Furthermore, positive MMP-1 expression in primary colorectal tumour tissues was a significant predictor of liver metastasis. However, the prognostic impact of protein marker expression in terms of intrahepatic recurrence appears to be minimal | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 217~225 | - |
dc.relation.isPartOf | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Carcinoembryonic Antigen/metabolism | - |
dc.subject.MESH | Colorectal Neoplasms/metabolism | - |
dc.subject.MESH | Colorectal Neoplasms/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/metabolism | - |
dc.subject.MESH | Liver Neoplasms/secondary* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Matrix Metalloproteinase 1/metabolism* | - |
dc.subject.MESH | Matrix Metalloproteinase 7/metabolism | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Tissue Inhibitor of Metalloproteinases/metabolism | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A/metabolism | - |
dc.title | A comparative study of protein expression in primary colorectal cancer and synchronous hepatic metastases: the significance of matrix metalloproteinase-1 expression as a predictor of liver metastasis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Young Wan Kim | - |
dc.contributor.googleauthor | Yong Taek Ko | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Hyun Cheol Chung | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Jong-pil Park | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.identifier.doi | 10.3109/00365520903453158 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00129 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A00720 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A01665 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J02632 | - |
dc.identifier.eissn | 1502-7708 | - |
dc.identifier.pmid | 20095886 | - |
dc.identifier.url | http://informahealthcare.com/doi/abs/10.3109/00365520903453158 | - |
dc.subject.keyword | Colonic neoplasm | - |
dc.subject.keyword | liver metastasis | - |
dc.subject.keyword | protein expression | - |
dc.contributor.alternativeName | Ko, Yong Taek | - |
dc.contributor.alternativeName | Kim, Nam Kyu | - |
dc.contributor.alternativeName | Kim, Young Wan | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Min, Byung Soh | - |
dc.contributor.alternativeName | Park, Jong Pil | - |
dc.contributor.alternativeName | Lee, Kang Young | - |
dc.contributor.alternativeName | Chung, Hyun Cheol | - |
dc.contributor.affiliatedAuthor | Ko, Yong Taek | - |
dc.contributor.affiliatedAuthor | Kim, Nam Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Young Wan | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Min, Byung Soh | - |
dc.contributor.affiliatedAuthor | Park, Jong Pil | - |
dc.contributor.affiliatedAuthor | Lee, Kang Young | - |
dc.contributor.affiliatedAuthor | Chung, Hyun Cheol | - |
dc.citation.volume | 45 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 217 | - |
dc.citation.endPage | 225 | - |
dc.identifier.bibliographicCitation | SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, Vol.45(2) : 217-225, 2010 | - |
dc.identifier.rimsid | 51035 | - |
dc.type.rims | ART | - |
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