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Predictors of kidney volume change and delayed kidney function recovery after donor nephrectomy

Authors
 Hwang Gyun Jeon  ;  Seung Ryeol Lee  ;  Dong Jin Joo  ;  Young Taik Oh  ;  Myoung Soo Kim  ;  Yu Seun Kim  ;  Seung Choul Yang  ;  Woong Kyu Han 
Citation
 JOURNAL OF UROLOGY, Vol.184(3) : 1057-1063, 2010 
Journal Title
 JOURNAL OF UROLOGY 
ISSN
 0022-5347 
Issue Date
2010
MeSH
Adolescent ; Adult ; Aged ; Female ; Humans ; Kidney/anatomy & histology* ; Kidney/physiology* ; Living Donors* ; Male ; Middle Aged ; Nephrectomy* ; Organ Size ; Prognosis ; Prospective Studies ; Recovery of Function* ; Time Factors ; Young Adult
Keywords
kidney transplantation ; living donors ; kidney function tests ; tomography, emission-computed ; organ size
Abstract
PURPOSE: To our knowledge the effects of preoperative kidney volume in living donors on the post-donation change in size and function of the remaining kidney have not been investigated. We studied the association between preoperative kidney volume, and volume change and delayed kidney function recovery in donors. MATERIALS AND METHODS: From 2007 to 2008 we investigated 222 living donors. Kidney volume before and 6 months after surgery was estimated using the voxel count method. We analyzed correlations of kidney volume with patient characteristics, kidney function and actual kidney weight. To identify predictors of the volume increase of the remaining kidney and predictors of delayed kidney function recovery we performed regression analysis. RESULTS: Mean +/- SD total kidney volume was 311.9 +/- 50.6 cc and it correlated with weight, body surface area and kidney function (p <0.001). The mean volume increase in the remaining kidney was 27.6% +/- 9.7% (range 4.5% to 66.1%). Younger age (p <0.001) and lower preoperative volume of the remaining kidney (p = 0.019) were significant predictors of a greater increase in kidney volume on multiple linear regression analysis. Older age (OR 1.07, p <0.001), higher body mass index (OR 1.20, p = 0.008), lower preoperative kidney volume of the remaining kidney (OR 0.98, p = 0.003) and a lower preoperative diethylenetetramine pentaacetic acid glomerular filtration rate in the remaining kidney (OR 0.95, p = 0.017) were significant predictors of delayed kidney function recovery on multiple regression analysis. CONCLUSIONS: Kidney volume measured by the voxel count method was accurate and correlated with kidney function. Preoperative kidney volume is an independent predictor of the volume increase and delayed kidney function recovery in donors that could be used clinically
Full Text
http://www.sciencedirect.com/science/article/pii/S0022534710035147
DOI
10.1016/j.juro.2010.04.079
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Yang, Seung Choul(양승철)
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
Joo, Dong Jin(주동진) ORCID logo https://orcid.org/0000-0001-8405-1531
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101384
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