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A case of acute phosphate nephropathy in a patient with nephrotic syndrome and decreased serum fetuin-A

Authors
 S.H. Han  ;  J.E. Lee  ;  S.H. Lee  ;  J.J. Li  ;  S.W. Hong  ;  D.S. Han  ;  S.-W. Kang 
Citation
 CLINICAL NEPHROLOGY, Vol.74(2) : 159-163, 2010 
Journal Title
 CLINICAL NEPHROLOGY 
ISSN
 0301-0430 
Issue Date
2010
MeSH
Acute Disease ; Acute Kidney Injury/chemically induced* ; Administration, Oral ; Biopsy ; Blood Proteins/metabolism* ; Cathartics/administration & dosage ; Cathartics/adverse effects* ; Colonoscopy ; Creatinine/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Middle Aged ; Nephrotic Syndrome/complications* ; Phosphates/administration & dosage ; Phosphates/adverse effects* ; alpha-2-HS-Glycoprotein
Keywords
acute phosphate nephropathy ; oral sodium phosphate ; nephrotic syndrome ; fetuin-A
Abstract
We report a case of APN after OSP use in a patient with nephrotic syndrome (NS). Renal biopsy revealed minimal change disease with multifocal calcium phosphate deposits within the tubules and in the interstitium. The serum level of fetuin-A, a systemic calcification inhibitor, was low during severely proteinuric state but normalized after remission of NS. To verify whether fetuin-A levels are low in NS patients, serum fetuin-A levels were determined in 10 patients with NS and 10 with asymptomatic microscopic hematuria (H). The mean serum fetuin-A levels were significantly lower in the NS group compared to the H group (p < 0.01). This finding suggests that a lower serum fetuin-A level may be associated with APN after OSP use in patients with NS, thus careful attention should be paid when colonoscopy using OSP is scheduled in this population.
Full Text
http://www.dustri.com/index.php?id=98&artId=7743
DOI
10.5414/CNP74159
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Li, Jin Ji(이금희)
Lee, Sun Ha(이순하)
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Han, Dae Suk(한대석)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101354
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