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A case of acute phosphate nephropathy in a patient with nephrotic syndrome and decreased serum fetuin-A

Authors
 S.H. Han  ;  J.E. Lee  ;  S.H. Lee  ;  J.J. Li  ;  S.W. Hong  ;  D.S. Han  ;  S.-W. Kang 
Citation
 Clinical Nephrology, Vol.74(2) : 159-163, 2010 
Journal Title
 Clinical Nephrology 
ISSN
 0301-0430 
Issue Date
2010
Abstract
We report a case of APN after OSP use in a patient with nephrotic syndrome (NS). Renal biopsy revealed minimal change disease with multifocal calcium phosphate deposits within the tubules and in the interstitium. The serum level of fetuin-A, a systemic calcification inhibitor, was low during severely proteinuric state but normalized after remission of NS. To verify whether fetuin-A levels are low in NS patients, serum fetuin-A levels were determined in 10 patients with NS and 10 with asymptomatic microscopic hematuria (H). The mean serum fetuin-A levels were significantly lower in the NS group compared to the H group (p < 0.01). This finding suggests that a lower serum fetuin-A level may be associated with APN after OSP use in patients with NS, thus careful attention should be paid when colonoscopy using OSP is scheduled in this population.
Full Text
http://www.dustri.com/index.php?id=98&artId=7743
DOI
10.5414/CNP74159
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
강신욱(Kang, Shin Wook) ORCID logo https://orcid.org/0000-0002-5677-4756
이금희(Li, Jin Ji)
이순하(Lee, Sun Ha)
이정은(Lee, Jung Eun) ORCID logo https://orcid.org/0000-0003-0917-2872
한대석(Han, Dae Suk)
한승혁(Han, Seung Hyeok) ORCID logo https://orcid.org/0000-0001-7923-5635
홍순원(Hong, Soon Won) ORCID logo https://orcid.org/0000-0002-0324-2414
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101354
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