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A case of acute phosphate nephropathy in a patient with nephrotic syndrome and decreased serum fetuin-A

 S.H. Han  ;  J.E. Lee  ;  S.H. Lee  ;  J.J. Li  ;  S.W. Hong  ;  D.S. Han  ;  S.-W. Kang 
 CLINICAL NEPHROLOGY, Vol.74(2) : 159-163, 2010 
Journal Title
Issue Date
Acute Disease ; Acute Kidney Injury/chemically induced* ; Administration, Oral ; Biopsy ; Blood Proteins/metabolism* ; Cathartics/administration & dosage ; Cathartics/adverse effects* ; Colonoscopy ; Creatinine/blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Middle Aged ; Nephrotic Syndrome/complications* ; Phosphates/administration & dosage ; Phosphates/adverse effects* ; alpha-2-HS-Glycoprotein
acute phosphate nephropathy ; oral sodium phosphate ; nephrotic syndrome ; fetuin-A
We report a case of APN after OSP use in a patient with nephrotic syndrome (NS). Renal biopsy revealed minimal change disease with multifocal calcium phosphate deposits within the tubules and in the interstitium. The serum level of fetuin-A, a systemic calcification inhibitor, was low during severely proteinuric state but normalized after remission of NS. To verify whether fetuin-A levels are low in NS patients, serum fetuin-A levels were determined in 10 patients with NS and 10 with asymptomatic microscopic hematuria (H). The mean serum fetuin-A levels were significantly lower in the NS group compared to the H group (p < 0.01). This finding suggests that a lower serum fetuin-A level may be associated with APN after OSP use in patients with NS, thus careful attention should be paid when colonoscopy using OSP is scheduled in this population.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Li, Jin Ji(이금희)
Lee, Sun Ha(이순하)
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Han, Dae Suk(한대석)
Han, Seung Hyeok(한승혁) ORCID logo https://orcid.org/0000-0001-7923-5635
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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