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Wogonin inhibits osteoclast formation induced by lipopolysaccharide

Authors
 Sungil Jang  ;  Eun Jung Bak  ;  Minyoung Kim  ;  Jin Moon Kim  ;  Won-Yoon Chung  ;  Jeong-Heon Cha  ;  Yun-Jung Yoo 
Citation
 Phytotherapy Research, Vol.24(7) : 964-968, 2010 
Journal Title
 Phytotherapy Research 
ISSN
 0951-418X 
Issue Date
2010
MeSH
Animals ; Bone Resorption/metabolism ; Cell Differentiation ; Cells, Cultured ; Coculture Techniques ; Cyclooxygenase Inhibitors/pharmacology ; Dinoprostone/biosynthesis ; Drugs, Chinese Herbal/pharmacology* ; Flavanones/pharmacology* ; Lipopolysaccharides/pharmacology* ; Male ; Mice ; Mice, Inbred BALB C ; Nitrobenzenes/pharmacology ; Osteoclasts/drug effects* ; Osteoprotegerin/metabolism ; RANK Ligand/metabolism ; Sulfonamides/pharmacology
Keywords
wogonin ; osteoclastogenesis ; lipopolysaccharide
Abstract
To evaluate the inhibitory activity of wogonin against lipopolysaccharide (LPS)-induced bone resorption, we investigated the effect of wogonin on osteoclastogenesis induced by LPS. Wogonin inhibited LPS-induced osteoclastogenesis in co-cultures of mouse calvaria-derived osteoblasts and bone marrow-derived pre-osteoclasts. Wogonin also suppressed osteoclastogenesis in LPS-injected mouse calvaria. In osteoblasts, the upregulation of receptor activator of nuclear factor-kappaB (RANKL) expression and the downregulation of osteoprotegerin (OPG) expression by LPS were inhibited by wogonin. Wogonin and NS-398, a COX-2 inhibitor, suppressed LPS-stimulated PGE(2) production in osteoblasts. NS-398 inhibited the effect of LPS on RANKL and OPG expression in osteoblasts. These results suggest that wogonin acts as an inhibitor of LPS-induced osteoclastogenesis through downregulation of RANKL and upregulation of OPG expression via blockage of PGE(2) production. Based on these results, wogonin has potential for use as a therapeutic agent in bacteria-induced bone resorption.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/ptr.3013/abstract
DOI
10.1002/ptr.3013
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Min Young(김민영)
Kim, Jin Moon(김진문)
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Jang, Sungil(장성일) ORCID logo https://orcid.org/0000-0001-6144-6899
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
Cha, Jung Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101348
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