Cited 5 times in
Wogonin inhibits osteoclast formation induced by lipopolysaccharide
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장성일 | - |
dc.contributor.author | 정원윤 | - |
dc.contributor.author | 차정헌 | - |
dc.contributor.author | 김민영 | - |
dc.contributor.author | 김진문 | - |
dc.contributor.author | 유윤정 | - |
dc.date.accessioned | 2015-04-23T16:51:07Z | - |
dc.date.available | 2015-04-23T16:51:07Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101348 | - |
dc.description.abstract | To evaluate the inhibitory activity of wogonin against lipopolysaccharide (LPS)-induced bone resorption, we investigated the effect of wogonin on osteoclastogenesis induced by LPS. Wogonin inhibited LPS-induced osteoclastogenesis in co-cultures of mouse calvaria-derived osteoblasts and bone marrow-derived pre-osteoclasts. Wogonin also suppressed osteoclastogenesis in LPS-injected mouse calvaria. In osteoblasts, the upregulation of receptor activator of nuclear factor-kappaB (RANKL) expression and the downregulation of osteoprotegerin (OPG) expression by LPS were inhibited by wogonin. Wogonin and NS-398, a COX-2 inhibitor, suppressed LPS-stimulated PGE(2) production in osteoblasts. NS-398 inhibited the effect of LPS on RANKL and OPG expression in osteoblasts. These results suggest that wogonin acts as an inhibitor of LPS-induced osteoclastogenesis through downregulation of RANKL and upregulation of OPG expression via blockage of PGE(2) production. Based on these results, wogonin has potential for use as a therapeutic agent in bacteria-induced bone resorption. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 964~968 | - |
dc.relation.isPartOf | PHYTOTHERAPY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Resorption/metabolism | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Coculture Techniques | - |
dc.subject.MESH | Cyclooxygenase Inhibitors/pharmacology | - |
dc.subject.MESH | Dinoprostone/biosynthesis | - |
dc.subject.MESH | Drugs, Chinese Herbal/pharmacology* | - |
dc.subject.MESH | Flavanones/pharmacology* | - |
dc.subject.MESH | Lipopolysaccharides/pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Nitrobenzenes/pharmacology | - |
dc.subject.MESH | Osteoclasts/drug effects* | - |
dc.subject.MESH | Osteoprotegerin/metabolism | - |
dc.subject.MESH | RANK Ligand/metabolism | - |
dc.subject.MESH | Sulfonamides/pharmacology | - |
dc.title | Wogonin inhibits osteoclast formation induced by lipopolysaccharide | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Sungil Jang | - |
dc.contributor.googleauthor | Eun Jung Bak | - |
dc.contributor.googleauthor | Minyoung Kim | - |
dc.contributor.googleauthor | Jin Moon Kim | - |
dc.contributor.googleauthor | Won-Yoon Chung | - |
dc.contributor.googleauthor | Jeong-Heon Cha | - |
dc.contributor.googleauthor | Yun-Jung Yoo | - |
dc.identifier.doi | 10.1002/ptr.3013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03440 | - |
dc.contributor.localId | A03676 | - |
dc.contributor.localId | A04007 | - |
dc.contributor.localId | A01014 | - |
dc.contributor.localId | A02490 | - |
dc.contributor.localId | A00465 | - |
dc.relation.journalcode | J02531 | - |
dc.identifier.eissn | 1099-1573 | - |
dc.identifier.pmid | 19998398 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/ptr.3013/abstract | - |
dc.subject.keyword | wogonin | - |
dc.subject.keyword | osteoclastogenesis | - |
dc.subject.keyword | lipopolysaccharide | - |
dc.contributor.alternativeName | Jang, Sung Il | - |
dc.contributor.alternativeName | Chung, Won Yoon | - |
dc.contributor.alternativeName | Cha, Jung Heon | - |
dc.contributor.alternativeName | Kim, Min Young | - |
dc.contributor.alternativeName | Kim, Jin Moon | - |
dc.contributor.alternativeName | Yoo, Yun Jung | - |
dc.contributor.affiliatedAuthor | Jang, Sungil | - |
dc.contributor.affiliatedAuthor | Chung, Won Yoon | - |
dc.contributor.affiliatedAuthor | Cha, Jung Heon | - |
dc.contributor.affiliatedAuthor | Kim, Jin Moon | - |
dc.contributor.affiliatedAuthor | Yoo, Yun Jung | - |
dc.contributor.affiliatedAuthor | Kim, Min Young | - |
dc.citation.volume | 24 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 964 | - |
dc.citation.endPage | 968 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, Vol.24(7) : 964-968, 2010 | - |
dc.identifier.rimsid | 50999 | - |
dc.type.rims | ART | - |
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