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Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodium.

 Ji Soo Choi  ;  Myeong-Jin Kim  ;  Jin-Young Choi  ;  Mi-Suk Park  ;  Joon Seok Lim  ;  Ki Whang Kim 
 EUROPEAN RADIOLOGY, Vol.20(5) : 1052-1060, 2010 
Journal Title
Issue Date
Adult ; Aged ; Carcinoma, Hepatocellular/pathology ; Cholangiocarcinoma/pathology ; Contrast Media/administration & dosage* ; Cysts/pathology ; Female ; Gadolinium DTPA/administration & dosage* ; Hemangioma/pathology ; Humans ; Image Interpretation, Computer-Assisted ; Injections, Intravenous ; Liver Neoplasms/pathology* ; Male ; Middle Aged ; Statistics, Nonparametric
Diffusion-weighted imaging Magnetic resonance imaging 3.0 T Gadoxetic acid disodium Hepatic lesion
OBJECTIVE: To determine whether intravenous administration of gadoxetic acid disodium (Gd-EOB-DTPA) affects lesion conspicuity and apparent diffusion coefficient (ADCs) in diffusion-weighted imaging (DWI) for hepatic magnetic resonance imaging (MRI) at 3.0 T.

METHODS: Thirty-four patients with 50 focal hepatic lesions (18 hepatocellular carcinomas, 12 metastases, 1 cholangiocarcinoma, 7 haemangiomas, 12 cysts) underwent DWI at 3.0 T before and after administration of Gd-EOB-DTPA. Non-breath-hold DWI was performed with b values of 0, 200, 400 and 800 s/mm(2). Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of each lesion, and ADCs of the liver and lesion were calculated for unenhanced and enhanced images. Statistical differences between unenhanced and enhanced data were assessed.

RESULTS: SNRs and ADCs of the liver on enhanced images were significantly lower than on unenhanced images. On DW images at b = 200 s/mm(2), CNRs of malignant and overall lesions were significantly higher on enhanced than on unenhanced images. CNRs of focal lesions tended to be higher, especially in malignant lesions, on DW images at b = 0 and 400 s/mm(2), but without reaching statistical significance. ADCs of focal hepatic lesions were not significantly different before and after administration of contrast agent.

CONCLUSION: DWI after Gd-EOB-DTPA administration can be used as a substitute for unenhanced DWI at 3.0 T without compromising CNR and ADC of focal hepatic lesions.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
Choi, Ji Soo(최지수)
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
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