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Association between resting heart rate and arterial stiffness in Korean adults

Authors
 Byoung-Jin Park  ;  Hye-Ree Lee  ;  Jae-Yong Shim  ;  Jung-Hyun Lee  ;  Dong-Hyuk Jung  ;  Yong-Jae Lee 
Citation
 Archives of Cardiovascular Diseases, Vol.103(4) : 246-252, 2010 
Journal Title
 Archives of Cardiovascular Diseases 
ISSN
 1875-2136 
Issue Date
2010
Abstract
BACKGROUND: Higher resting heart rate, a simple and useful indicator of autonomic balance and metabolic rate, has emerged as an independent predictor for atherosclerotic cardiovascular disease. AIM: To determine the association between resting heart rate and arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV). METHODS: We examined the association between resting heart rate and baPWV in 641 Korean adults (366 men, 275 women) in a health examination program. A high baPWV was defined as greater than 1450 cm/s (>75th percentile). The odds ratios for high baPWVs were calculated using multivariable logistic regression analysis after adjusting for confounding variables across heart rate quartiles (Q1<or=56, Q2=57-62, Q3=63-68, Q4>or=69 beats/min). RESULTS: Age-adjusted baPWV mean values increased gradually with heart rate quartile (Q1=1281, Q2=1285, Q3=1354, Q4=1416 cm/s). The odds ratios (95% confidence intervals) for high baPWVs in each heart rate quartile were 1.00, 1.28 (0.57-2.86), 2.63 (1.20-5.79) and 3.66 (1.66-8.05), respectively, after adjusting for age, sex, smoking status, alcohol intake, exercise, body mass index, hypertension medication, diabetes medication, hyperlipidaemia medication, mean arterial blood pressure, fasting plasma glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, white blood cell count, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase and uric acid. CONCLUSION: These findings indicate that a higher resting heart rate is independently associated with arterial stiffness. Accordingly, early detection of increased resting heart rate is important for preservation of arterial function and assessment of cardiovascular risk.
Full Text
http://www.sciencedirect.com/science/article/pii/S1875213610000690
DOI
10.1016/j.acvd.2010.03.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Byoung Jin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101279
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