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Epithelial-mesenchymal transition in osteogenic sarcoma of the neck following oral squamous cell carcinoma

Other Titles
 구강 편평세포암종 제거 후 발생한 경부 골육종에서의 상피간엽이행 
 Hyun Sil Kim  ;  Nam Hee Kim  ;  Seon Hui Han  ;  In Ho Cha  ;  Dong Jun Seo  ;  Wonse Park  ;  Jong In Yook  ;  Hyung Jun Kim 
 Journal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지), Vol.36(3) : 172-176, 2010 
Journal Title
Journal of the Korean Association of Oral and Maxillofacial Surgeons(대한구강악안면외과학회지)
Issue Date
Squamous cell carcinoma (SCC) ; Extraosseous osteogenic sarcoma (EOS) ; Epithelial-mesenchymal transition (EMT) ; Snail ; E-cadherin ; Mouth neopla는
Postirradiation extraosseous osteogenic sarcomas are uncommon in the head and neck, despite the extensive use of high-dose radiation. It has been described as de novo radiation-induced neoplasm. We present a 73-year-old male who had been treated by radiotherapy for gingival cancer 7 years earlier and later developed extraosseous osteogenic sarcomas (EOSs) of the neck. Microscopically, the neck mass was composed with mesenchymal malignant cells with cartilaginous and osteogenic differentiation. Immunohistochemical stain demonstrated strong positivity of tumor cells for Snail, the one of major epithelial-mesenchymal transition (EMT) inducer. The E-cadherin expression was scarce, showing inverse relationship to Snail expression. Compared with previous squamous cell carcinoma (SCC) of the gingiva, the present EOS sample revealed the remained epithelial cells on cytokeratin immunohistochemistry, suggesting the tumor arise from the cells of epithelial origin. We have also reviewed the previous 6 cases of head and neck EOSs carefully. The clinicopathologic features of the unusual lesion suggest that it is an incomplete EMT of precedent epithelial malignancy rather than de novo pathology.
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2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Hee(김남희) ORCID logo https://orcid.org/0000-0002-3087-5276
Kim, Hyun Sil(김현실) ORCID logo https://orcid.org/0000-0003-3614-1764
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
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