240 402

Cited 0 times in

Epithelial-mesenchymal transition in osteogenic sarcoma of the neck following oral squamous cell carcinoma

DC FieldValueLanguage
dc.contributor.author김남희-
dc.contributor.author김현실-
dc.contributor.author김형준-
dc.contributor.author박원서-
dc.contributor.author육종인-
dc.contributor.author차인호-
dc.date.accessioned2015-04-23T16:48:51Z-
dc.date.available2015-04-23T16:48:51Z-
dc.date.issued2010-
dc.identifier.issn1225-1585-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101276-
dc.description.abstractPostirradiation extraosseous osteogenic sarcomas are uncommon in the head and neck, despite the extensive use of high-dose radiation. It has been described as de novo radiation-induced neoplasm. We present a 73-year-old male who had been treated by radiotherapy for gingival cancer 7 years earlier and later developed extraosseous osteogenic sarcomas (EOSs) of the neck. Microscopically, the neck mass was composed with mesenchymal malignant cells with cartilaginous and osteogenic differentiation. Immunohistochemical stain demonstrated strong positivity of tumor cells for Snail, the one of major epithelial-mesenchymal transition (EMT) inducer. The E-cadherin expression was scarce, showing inverse relationship to Snail expression. Compared with previous squamous cell carcinoma (SCC) of the gingiva, the present EOS sample revealed the remained epithelial cells on cytokeratin immunohistochemistry, suggesting the tumor arise from the cells of epithelial origin. We have also reviewed the previous 6 cases of head and neck EOSs carefully. The clinicopathologic features of the unusual lesion suggest that it is an incomplete EMT of precedent epithelial malignancy rather than de novo pathology.-
dc.description.statementOfResponsibilityopen-
dc.format.extent172~176-
dc.relation.isPartOfJournal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEpithelial-mesenchymal transition in osteogenic sarcoma of the neck following oral squamous cell carcinoma-
dc.title.alternative구강 편평세포암종 제거 후 발생한 경부 골육종에서의 상피간엽이행-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of General Dentistry (통합진료학)-
dc.contributor.googleauthorHyun Sil Kim-
dc.contributor.googleauthorNam Hee Kim-
dc.contributor.googleauthorSeon Hui Han-
dc.contributor.googleauthorIn Ho Cha-
dc.contributor.googleauthorDong Jun Seo-
dc.contributor.googleauthorWonse Park-
dc.contributor.googleauthorJong In Yook-
dc.contributor.googleauthorHyung Jun Kim-
dc.identifier.doi10.5125/jkaoms.2010.36.3.172-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00360-
dc.contributor.localIdA01121-
dc.contributor.localIdA01589-
dc.contributor.localIdA02536-
dc.contributor.localIdA04002-
dc.relation.journalcodeJ01806-
dc.subject.keywordSquamous cell carcinoma (SCC)-
dc.subject.keywordExtraosseous osteogenic sarcoma (EOS)-
dc.subject.keywordEpithelial-mesenchymal transition (EMT)-
dc.subject.keywordSnail-
dc.subject.keywordE-cadherin-
dc.subject.keywordMouth neopla는-
dc.contributor.alternativeNameKim, Nam Hee-
dc.contributor.alternativeNameKim, Hyun Sil-
dc.contributor.alternativeNameKim, Hyung Jun-
dc.contributor.alternativeNamePark, Wonse-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.affiliatedAuthorKim, Nam Hee-
dc.contributor.affiliatedAuthorKim, Hyun Sil-
dc.contributor.affiliatedAuthorPark, Wonse-
dc.contributor.affiliatedAuthorYook, Jong In-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.citation.volume36-
dc.citation.number3-
dc.citation.startPage172-
dc.citation.endPage176-
dc.identifier.bibliographicCitationJournal of the Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회지), Vol.36(3) : 172-176, 2010-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.