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Liposomes coloaded with iopamidol/lipiodol as a RES-targeted contrast agent for computed tomography imaging

Authors
 Soonjae Kweon  ;  Ho-Joon Lee  ;  Woo Jin Hyung  ;  Jinsuk Suh  ;  Joon Seok Lim  ;  Soo-Jeong Lim 
Citation
 PHARMACEUTICAL RESEARCH, Vol.27(7) : 1408-1415, 2010 
Journal Title
 PHARMACEUTICAL RESEARCH 
ISSN
 0724-8741 
Issue Date
2010
MeSH
Animals ; Contrast Media/pharmacology* ; Drug Delivery Systems ; Female ; Iodized Oil/pharmacology* ; Iopamidol/pharmacology* ; Liposomes/chemistry* ; Mononuclear Phagocyte System/drug effects* ; Rats ; Tomography, X-Ray Computed/methods*
Abstract
PURPOSE: The need for computed tomography (CT) of reticuloendothelial system (RES)-rich organs such as the liver is increasing, particularly in patients with suspected hepatic metastasis. CT images of the liver have been improved by encapsulating currently used, water-soluble iodine contrast agent in liposomes. The present study was performed to investigate a possibility to overcome the limitations of entrapped iodine in liposomes by preparing liposomes co-loaded with iopamidol, a water-soluble iodinated compound, and lipiodol, an iodized oil. METHODS: Iopamidol and lipiodol were simultaneously loaded in liposomes by modified reverse-phase evaporation method. The entrapped iodine concentration, mean particle size and polydispersity index of resulting liposomes were evaluated. Following intravenous injection of these liposomes into rats, CT scanning was performed. RESULTS: Simultaneous loading of iopamidol and lipiodol into liposomes resulted in entrapped iodine concentrations as high as 49.2 iodine mg/ml. The mean particle size was 280 nm, and the mean polydispersity index was 0.230. CT scanning with these iopamidol/lipiodol (I/L) liposomes into rats resulted in more pronounced and more persistent increases in RES-rich organs, liver and spleen, compared with free liposomes or liposomes loaded with iopamidol alone. CONCLUSIONS: These findings indicate that I/L liposomes have the potential to allow thorough CT examination of RES-rich organs.
Full Text
http://link.springer.com/article/10.1007%2Fs11095-010-0135-5
DOI
10.1007/s11095-010-0135-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Lim, Joon Seok(임준석) ORCID logo https://orcid.org/0000-0002-0334-5042
Hyung, Woo Jin(형우진) ORCID logo https://orcid.org/0000-0002-8593-9214
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101202
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