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Quantification of superparamagnetic iron oxide-mediated signal intensity change in patients with liver cirrhosis using T2 and T2* mapping: a preliminary report.

Authors
 Yong Eun Chung  ;  Mi-Suk Park  ;  Myoung Soo Kim  ;  Eunju Kim  ;  Jaeseok Park  ;  Ho-Taek Song  ;  Jin Young Choi  ;  Myeong-Jin Kim  ;  Ki Whang Kim 
Citation
 JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.31(6) : 1379-1386, 2010 
Journal Title
 JOURNAL OF MAGNETIC RESONANCE IMAGING 
ISSN
 1053-1807 
Issue Date
2010
Keywords
magnetic resonance imaging ; relaxometry ; liver cirrhosis ; contrast agent ; superparamagnetic iron oxide
Abstract
PURPOSE: To quantify the accumulation of superparamagnetic iron oxide (SPIO) in patients with and without liver cirrhosis using T2 and T2* mapping. MATERIALS AND METHODS: We enrolled 10 patients without liver cirrhosis and 30 patients with liver cirrhosis (Child-Pugh class A, n = 18; and B/C, n = 12). T2 and T2* mapping were performed before and after SPIO administration. The reductions in T2 (DeltaT2) and T2* (DeltaT2*) after SPIO administration were compared between the control and liver cirrhosis groups and the control, Child-Pugh A, and Child Pugh B/C groups. RESULTS: There were significant differences in DeltaT2 (22.2 +/- 4.4 and 15.1 +/- 7.0) and DeltaT2* values (24.3 +/- 3.3 and 16.8 +/- 8.1) (P = 0.005 and P < 0.001) between the control and the liver cirrhosis groups. There was a significant difference in the DeltaT2* between the Child-Pugh A and Child-Pugh B/C groups (P < 0.001) and in the DeltaT2 and DeltaT2* between the control and Child-Pugh B/C groups (P = 0.018 and P < 0.001). CONCLUSION: DeltaT2 and DeltaT2* are significantly larger in patients without liver cirrhosis than those with liver cirrhosis. DeltaT2* is also significantly larger in Child-Pugh class A patients than those in Child-Pugh B/C.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jmri.22184/abstract
DOI
10.1002/jmri.22184
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Park, Jae Seok(박재석)
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101196
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