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Intravitreal bevacizumab in the management of subretinal fluid associated with choroidal osteoma

Authors
 Song, Ji Hun  ;  Bae, Jeong Hun  ;  Rho, Mi In  ;  Lee, Sung Chul 
Citation
 RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, Vol.30(6) : 945-951, 2010 
Journal Title
 RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 
ISSN
 0275-004X 
Issue Date
2010
MeSH
Adult ; Angiogenesis Inhibitors/administration & dosage* ; Antibodies, Monoclonal/administration & dosage* ; Antibodies, Monoclonal, Humanized ; Bevacizumab ; Body Fluids/drug effects ; Bone Neoplasms/complications* ; Bone Neoplasms/pathology ; Choroid Neoplasms/complications* ; Choroid Neoplasms/pathology ; Exudates and Transudates/drug effects ; Female ; Fluorescein Angiography ; Humans ; Injections ; Male ; Middle Aged ; Osteoma/complications* ; Osteoma/pathology ; Retinal Detachment/drug therapy* ; Retinal Detachment/etiology ; Retrospective Studies ; Tomography, Optical Coherence ; Vascular Endothelial Growth Factor A/antagonists & inhibitors ; Visual Acuity/physiology ; Vitreous Body
Abstract
PURPOSE: The purpose of this study was to evaluate the effect of intravitreal injection of bevacizumab on subretinal fluid associated with choroidal osteoma. METHODS: In this retrospective noncomparative case series, eyes with serous retinal detachment involving the macula were treated with intravitreal injection of bevacizumab (1.25 mg/0.05 mL) and carefully followed-up with complete ophthalmic examination, including angiography and optical coherence tomography. The changes in best-corrected visual acuity and central foveal thickness were assessed by optical coherence tomography. RESULTS: Six eyes received intravitreal injection of bevacizumab for serous retinal detachment. Only one eye had choroidal neovascularization associated with serous retinal detachment. The mean number of injections for the 6 eyes was 2.0 during the mean follow-up period of 11.3 months. The median logarithm of the minimum angle of resolution best-corrected visual acuity improved from 0.70 (Snellen equivalent, 20/100) at baseline to 0.30 (Snellen equivalent, 20/40; P = 0.043) at the final visit. The optical coherence tomography result also showed a significant reduction in central foveal thickness with a median central foveal thickness of 357.0 microm at baseline and 169.50 microm at the final visit (P = 0.028). The treatment was well tolerated, without ocular or systemic adverse events. CONCLUSION: Intravitreal injection of bevacizumab for serous retinal detachment secondary to choroidal osteoma resulted in both visual and anatomical improvements.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006982-201006000-00015&LSLINK=80&D=ovft
DOI
10.1097/IAE.0b013e3181c720ca
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Roh, Mi In(노미인)
Lee, Sung Chul(이성철) ORCID logo https://orcid.org/0000-0001-9438-2385
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101177
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