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Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells

Authors
 Jie-Hyun Kim  ;  Yeun Jung Choi  ;  Sang Hun Lee  ;  Hyun Soo Shin  ;  In Ohk Lee  ;  Yu Jin Kim  ;  Hyunki Kim  ;  Woo Ick Yang  ;  Hoguen Kim  ;  Yong Chan Lee 
Citation
 ONCOLOGY REPORTS, Vol.23(6) : 1523-1528, 2010 
Journal Title
 ONCOLOGY REPORTS 
ISSN
 1021-335X 
Issue Date
2010
MeSH
Cell Line, Tumor ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism* ; Helicobacter Infections/metabolism* ; Helicobacter Infections/microbiology ; Helicobacter Infections/pathology ; Helicobacter pylori/pathogenicity* ; Humans ; Immunoblotting ; Patched Receptors ; Patched-1 Receptor ; RNA, Messenger/genetics ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism* ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction ; Stomach Neoplasms/metabolism* ; Stomach Neoplasms/microbiology ; Stomach Neoplasms/pathology ; Transcription Factors/genetics ; Transcription Factors/metabolism* ; Zinc Finger Protein GLI1
Keywords
gastric cancer ; sonic hedgehog ; Helicobacter pylori ; carcinogenesis
Abstract
This study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in gastric cancer. Shh, Patched (Ptch), and transcription factor Gli1 were overexpressed in H. pylori-infected gastric cancer cells. The oncoprotein, CagA positive H. pylori resulted in significantly higher Shh expression. Pretreatment with MG-132 or PDTC significantly lowered Shh expression. Significant overexpression of Shh and Gli1 were noted in H. pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-kappaB pathway in gastric cancer cells.
Full Text
http://www.spandidos-publications.com/or/23/6/1523?text=abstract
DOI
10.3892/or_00000791
Appears in Collections:
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Yoo Jin(김유진)
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Shin, Hyun Soo(신현수)
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
Choi, Youn Jeong(최연정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101119
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