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Cited 22 times in

Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells

DC Field Value Language
dc.contributor.author김유진-
dc.contributor.author김지현-
dc.contributor.author김현기-
dc.contributor.author양우익-
dc.contributor.author이용찬-
dc.contributor.author최연정-
dc.contributor.author신현수-
dc.date.accessioned2015-04-23T16:43:53Z-
dc.date.available2015-04-23T16:43:53Z-
dc.date.issued2010-
dc.identifier.issn1021-335X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101119-
dc.description.abstractThis study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in gastric cancer. Shh, Patched (Ptch), and transcription factor Gli1 were overexpressed in H. pylori-infected gastric cancer cells. The oncoprotein, CagA positive H. pylori resulted in significantly higher Shh expression. Pretreatment with MG-132 or PDTC significantly lowered Shh expression. Significant overexpression of Shh and Gli1 were noted in H. pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-kappaB pathway in gastric cancer cells.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfONCOLOGY REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHHedgehog Proteins/genetics-
dc.subject.MESHHedgehog Proteins/metabolism*-
dc.subject.MESHHelicobacter Infections/metabolism*-
dc.subject.MESHHelicobacter Infections/microbiology-
dc.subject.MESHHelicobacter Infections/pathology-
dc.subject.MESHHelicobacter pylori/pathogenicity*-
dc.subject.MESHHumans-
dc.subject.MESHImmunoblotting-
dc.subject.MESHPatched Receptors-
dc.subject.MESHPatched-1 Receptor-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHReceptors, Cell Surface/genetics-
dc.subject.MESHReceptors, Cell Surface/metabolism*-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHSignal Transduction-
dc.subject.MESHStomach Neoplasms/metabolism*-
dc.subject.MESHStomach Neoplasms/microbiology-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHTranscription Factors/genetics-
dc.subject.MESHTranscription Factors/metabolism*-
dc.subject.MESHZinc Finger Protein GLI1-
dc.titleEffect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentMedical Research Center (임상의학연구센터)-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorYeun Jung Choi-
dc.contributor.googleauthorSang Hun Lee-
dc.contributor.googleauthorHyun Soo Shin-
dc.contributor.googleauthorIn Ohk Lee-
dc.contributor.googleauthorYu Jin Kim-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorYong Chan Lee-
dc.identifier.doi10.3892/or_00000791-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01108-
dc.contributor.localIdA02174-
dc.contributor.localIdA02300-
dc.contributor.localIdA02988-
dc.contributor.localIdA04108-
dc.contributor.localIdA02836-
dc.contributor.localIdA00787-
dc.contributor.localIdA00996-
dc.relation.journalcodeJ02419-
dc.identifier.eissn1791-2431-
dc.identifier.pmid20428805-
dc.identifier.urlhttp://www.spandidos-publications.com/or/23/6/1523?text=abstract-
dc.subject.keywordgastric cancer-
dc.subject.keywordsonic hedgehog-
dc.subject.keywordHelicobacter pylori-
dc.subject.keywordcarcinogenesis-
dc.contributor.alternativeNameKim, Yoo Jin-
dc.contributor.alternativeNameKim, Ji Hyun-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameLee, Sang Hoon-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameChoi, Youn Jeong-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorChoi, Youn Jeong-
dc.contributor.affiliatedAuthorLee, Sang Hoon-
dc.contributor.affiliatedAuthorKim, Yoo Jin-
dc.contributor.affiliatedAuthorKim, Ji Hyun-
dc.citation.volume23-
dc.citation.number6-
dc.citation.startPage1523-
dc.citation.endPage1528-
dc.identifier.bibliographicCitationONCOLOGY REPORTS, Vol.23(6) : 1523-1528, 2010-
dc.identifier.rimsid50840-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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