Cited 22 times in
Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김유진 | - |
dc.contributor.author | 김지현 | - |
dc.contributor.author | 김현기 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 최연정 | - |
dc.contributor.author | 신현수 | - |
dc.date.accessioned | 2015-04-23T16:43:53Z | - |
dc.date.available | 2015-04-23T16:43:53Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/101119 | - |
dc.description.abstract | This study aimed to investigate the effect of Helicobacter pylori (H. pylori) infection on the sonic Hedgehog (Shh) signaling in gastric cancer. Shh, Patched (Ptch), and transcription factor Gli1 were overexpressed in H. pylori-infected gastric cancer cells. The oncoprotein, CagA positive H. pylori resulted in significantly higher Shh expression. Pretreatment with MG-132 or PDTC significantly lowered Shh expression. Significant overexpression of Shh and Gli1 were noted in H. pylori-infected compared to non-infected gastric cancer tissues. Conclusively, H. pylori activated the Shh signaling pathway in CagA-dependent manner partly through the NF-kappaB pathway in gastric cancer cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Hedgehog Proteins/genetics | - |
dc.subject.MESH | Hedgehog Proteins/metabolism* | - |
dc.subject.MESH | Helicobacter Infections/metabolism* | - |
dc.subject.MESH | Helicobacter Infections/microbiology | - |
dc.subject.MESH | Helicobacter Infections/pathology | - |
dc.subject.MESH | Helicobacter pylori/pathogenicity* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoblotting | - |
dc.subject.MESH | Patched Receptors | - |
dc.subject.MESH | Patched-1 Receptor | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | Receptors, Cell Surface/genetics | - |
dc.subject.MESH | Receptors, Cell Surface/metabolism* | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Stomach Neoplasms/metabolism* | - |
dc.subject.MESH | Stomach Neoplasms/microbiology | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.subject.MESH | Transcription Factors/genetics | - |
dc.subject.MESH | Transcription Factors/metabolism* | - |
dc.subject.MESH | Zinc Finger Protein GLI1 | - |
dc.title | Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Jie-Hyun Kim | - |
dc.contributor.googleauthor | Yeun Jung Choi | - |
dc.contributor.googleauthor | Sang Hun Lee | - |
dc.contributor.googleauthor | Hyun Soo Shin | - |
dc.contributor.googleauthor | In Ohk Lee | - |
dc.contributor.googleauthor | Yu Jin Kim | - |
dc.contributor.googleauthor | Hyunki Kim | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.contributor.googleauthor | Hoguen Kim | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.identifier.doi | 10.3892/or_00000791 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01108 | - |
dc.contributor.localId | A02174 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A04108 | - |
dc.contributor.localId | A02836 | - |
dc.contributor.localId | A00787 | - |
dc.contributor.localId | A00996 | - |
dc.relation.journalcode | J02419 | - |
dc.identifier.eissn | 1791-2431 | - |
dc.identifier.pmid | 20428805 | - |
dc.identifier.url | http://www.spandidos-publications.com/or/23/6/1523?text=abstract | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | sonic hedgehog | - |
dc.subject.keyword | Helicobacter pylori | - |
dc.subject.keyword | carcinogenesis | - |
dc.contributor.alternativeName | Kim, Yoo Jin | - |
dc.contributor.alternativeName | Kim, Ji Hyun | - |
dc.contributor.alternativeName | Kim, Hyun Ki | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Lee, Sang Hoon | - |
dc.contributor.alternativeName | Lee, Yong Chan | - |
dc.contributor.alternativeName | Choi, Youn Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Ki | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Lee, Yong Chan | - |
dc.contributor.affiliatedAuthor | Choi, Youn Jeong | - |
dc.contributor.affiliatedAuthor | Lee, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Yoo Jin | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hyun | - |
dc.citation.volume | 23 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1523 | - |
dc.citation.endPage | 1528 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, Vol.23(6) : 1523-1528, 2010 | - |
dc.identifier.rimsid | 50840 | - |
dc.type.rims | ART | - |
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