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Negative capsule endoscopy without subsequent enteroscopy does not predict lower long-term rebleeding rates in patients with obscure GI bleeding.

 Jae Jun Park  ;  Jae Hee Cheon  ;  Hee Man Kim  ;  Hyeun Sung Park  ;  Chang Mo Moon  ;  Jin Ha Lee  ;  Sung Pil Hong  ;  Tae Il Kim  ;  Won Ho Kim 
 GASTROINTESTINAL ENDOSCOPY, Vol.71(6) : 990-997, 2010 
Journal Title
Issue Date
Adult ; Aged ; Capsule Endoscopy* ; Endoscopy, Gastrointestinal ; Female ; Gastrointestinal Hemorrhage/etiology* ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Recurrence ; Retrospective Studies ; Risk Factors ; Time Factors
BACKGROUND: Capsule endoscopy (CE) is now widely accepted as a first-line diagnostic modality for obscure GI bleeding (OGIB). However, the clinical implications of negative results of CE studies remain unclear. OBJECTIVE: To investigate long-term (>1 year) outcomes for patients undergoing CE for OGIB and to identify risk factors associated with rebleeding. DESIGN AND SETTING: Retrospective study in a tertiary care hospital. METHODS: A total of 57 consecutive patients who had undergone CE for OGIB were enrolled and their pre- and post-CE clinical data were collected. Specific treatments were defined as treatments directly aimed at presumed bleeding causes including hemostasis and disease-specific medical therapy, whereas nonspecific treatments were defined as symptomatic treatments for anemia. RESULTS: Of the 57 patients, the indication for CE was obscure-overt bleeding in 46 patients and obscure-occult bleeding in 11 patients. Among 51 patients for whom long-term data were available, significant (P2) lesions were found in 23 (45.1%) patients. The overall rebleeding rate was 35.3% during a median follow-up duration of 31.7 months (range 12.8-58.0 months). There was no statistically significant difference in the cumulative rebleeding rate between patients with positive and negative CE results (34.8% vs 35.7%, respectively; P = .989). However, specific treatments after CE (hazard ratio, 0.111; 95% CI, 0.013-0.980; P = .043) significantly decreased rebleeding. LIMITATIONS: Small number of patients, retrospective study design. CONCLUSIONS: The rebleeding rate for patients with OGIB and negative CE results was substantial, indicating that these patients should be closely observed. However, specific treatment after CE significantly reduced the incidence of recurrent bleeding.
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6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Kim, Hee Man(김희만)
Moon, Chang Mo(문창모)
Park, Jae Jun(박재준)
Park, Hyeun Sung(박현성)
Lee, Jin Ha(이진하)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
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