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Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression

Authors
 Jung-Yoon Yoo  ;  Kyung-Chul Choi  ;  HeeBum Kang  ;  Young Jun Kim  ;  Jeongmin Lee  ;  Woo Jin Jun  ;  Mi-Jeong Kim  ;  Yoo-Hyun Lee  ;  Ok-Hee Lee  ;  Ho-Geun Yoon 
Citation
 FEBS LETTERS, Vol.584(11) : 2225-2230, 2010 
Journal Title
 FEBS LETTERS 
ISSN
 0014-5793 
Issue Date
2010
MeSH
Animals ; Gene Expression ; Histone Deacetylases/genetics* ; Histone Deacetylases/metabolism ; Histones/genetics*
Keywords
L3MBTL2 ; L(3)mbt-like 2 ; HDAC3 ; histone deacetylase 3 ; HMT ; histone methyltransferase ; ChIP ; chromatin immunoprecipitation ; L(3)mbt-like 2 ; Histone deacetylase 3 ; MBT domain ; Transcription
Abstract
This is the first report that L(3)mbt-like 2 (L3MBTL2) specifically interacts with the histone deacetylase domain of histone deacetylase 3 (HDAC3) via its MBT domain. Here, we show that L3MBTL2 selectively interacts with HDAC3, but not other class I HDACs. An in vitro peptide-binding assay demonstrated the specific association of HDAC3 with methylated histone-K20 tail and L3MBTL2. Furthermore, depletion of HDAC3 resulted in a decrease of methylated K20-H4, as well as an increase in acetylated histone H3. Consequently, HDAC3 knock-down selectively suppressed L3MBTL2-mediated transcriptional repression. Taken together, our results reveal the concerted action of both HDAC3 and L3MBTL2 in histone deacetylation and methylation-dependent transcriptional repression.
Full Text
http://www.sciencedirect.com/science/article/pii/S0014579310002723
DOI
10.1016/j.febslet.2010.03.048
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Bum(강희범)
Kim, Mi Jeong(김미정) ORCID logo https://orcid.org/0000-0002-0758-7145
Yoo, Jung Yoon(유정윤) ORCID logo https://orcid.org/0000-0001-9366-3863
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Lee, Ok Hee(이옥희)
Choi, Kyung Chul(최경철)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101094
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