Mitomycin C does not inhibit exacerbation of granular corneal dystrophy type II induced by refractive surface ablation

2 853

Cited 0 times in

Cited 25 times in

Authors: Ha, Byoung Jin ; Kim, Tae-im ; Choi, Seung-il ; Stulting, R Doyle ; Lee, Dong Ho ; Cho, Hyun-Soo ; Kim, Eung Kweon

MeSH: Adult ; Alkylating Agents/administration & dosage* ; Corneal Dystrophies, Hereditary/diagnosis ; Corneal Dystrophies, Hereditary/etiology ; Corneal Dystrophies, Hereditary/prevention & control* ; Corneal Opacity/diagnosis ; Corneal Opacity/etiology ; Corneal Opacity/prevention & control* ; Female ; Humans ; Keratectomy, Subepithelial, Laser-Assisted/adverse effects* ; Male ; Mitomycin/administration & dosage* ; Photography ; Photorefractive Keratectomy/adverse effects* ; Retrospective Studies ; Visual Acuity ; Young Adult

Keywords: granular corneal dystrophy type II ; avellino cornealdystrophy ; mitomycin C ; keratoepithelin ; BIGH3 ; surface ablation ; LASEK ; PRK ; PTK ; TGF-beta ; pentacam

Abstract: PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation.

METHODS: Ten eyes of patients with GCD II who underwent refractive corneal surface ablation with MMC were compared with 10 eyes that were not treated with MMC. Best spectacle-corrected visual acuity, the degree of corneal opacity, and contrast sensitivity were evaluated at least 3 years after surgery. Corneal opacities were quantified using Pentacam densitometry maps.

RESULTS: No measured between-group value showed a statistically significant difference.

CONCLUSION: Simultaneous application of MMC does not prevent exacerbation of GCD II after refractive corneal surface ablation

Full Text: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003226-201005000-00002&LSLINK=80&D=ovft

Appears in Collections:: 1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

Yonsei Authors: Kim, Eung Kweon(김응권) https://orcid.org/0000-0002-1453-8042
Kim, Tae-Im(김태임) https://orcid.org/0000-0001-6414-3842
Choi, Seung Il(최승일) https://orcid.org/0000-0001-7168-8795

Show full item record Find it @ YMLIB

YUHSpace: Mitomycin C does not inhibit exacerbation of granular corneal dystrophy type II induced by refractive surface ablation