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Mitomycin C does not inhibit exacerbation of granular corneal dystrophy type II induced by refractive surface ablation

Authors
 Ha, Byoung Jin  ;  Kim, Tae-im  ;  Choi, Seung-il  ;  Stulting, R Doyle  ;  Lee, Dong Ho  ;  Cho, Hyun-Soo  ;  Kim, Eung Kweon 
Citation
 CORNEA, Vol.29(5) : 490-496, 2010 
Journal Title
 CORNEA 
ISSN
 0277-3740 
Issue Date
2010
MeSH
Adult ; Alkylating Agents/administration & dosage* ; Corneal Dystrophies, Hereditary/diagnosis ; Corneal Dystrophies, Hereditary/etiology ; Corneal Dystrophies, Hereditary/prevention & control* ; Corneal Opacity/diagnosis ; Corneal Opacity/etiology ; Corneal Opacity/prevention & control* ; Female ; Humans ; Keratectomy, Subepithelial, Laser-Assisted/adverse effects* ; Male ; Mitomycin/administration & dosage* ; Photography ; Photorefractive Keratectomy/adverse effects* ; Retrospective Studies ; Visual Acuity ; Young Adult
Keywords
granular corneal dystrophy type II ; avellino cornealdystrophy ; mitomycin C ; keratoepithelin ; BIGH3 ; surface ablation ; LASEK ; PRK ; PTK ; TGF-beta ; pentacam
Abstract
PURPOSE: To evaluate the effect of mitomycin C (MMC) on the exacerbation of corneal opacity that occurs in patients with granular corneal dystrophy type II (GCD II) after refractive corneal surface ablation. METHODS: Ten eyes of patients with GCD II who underwent refractive corneal surface ablation with MMC were compared with 10 eyes that were not treated with MMC. Best spectacle-corrected visual acuity, the degree of corneal opacity, and contrast sensitivity were evaluated at least 3 years after surgery. Corneal opacities were quantified using Pentacam densitometry maps. RESULTS: No measured between-group value showed a statistically significant difference. CONCLUSION: Simultaneous application of MMC does not prevent exacerbation of GCD II after refractive corneal surface ablation
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003226-201005000-00002&LSLINK=80&D=ovft
DOI
10.1097/ICO.0b013e3181c3258a
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Corneal Dystrophy Research Institute (각막이상증연구소) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Choi, Seung Il(최승일) ORCID logo https://orcid.org/0000-0001-7168-8795
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101078
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