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Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8

Authors
 Hyun Joo Chung  ;  Ji-Yeon Lee  ;  Custer C. Deocaris  ;  HyehyunMin  ;  Sang Hoon Kim  ;  Myoung Hee Kim 
Citation
 Journal of Biomedicine & Biotechnology, Vol.2010 : 231708, 2010 
Journal Title
 Journal of Biomedicine & Biotechnology 
ISSN
 1110-7243 
Issue Date
2010
Abstract
Using a ChIP-cloning technique, we identified a Zinc finger protein 804a (Zfp804a) as one of the putative Hoxc8 downstream target genes. We confirmed binding of Hoxc8 to an intronic region of Zfp804a by ChIP-PCR in F9 cells as well as in mouse embryos. Hoxc8 upregulated Zfp804a mRNA levels and augmented minimal promoter activity in vitro. In E11.5 mouse embryos, Zfp804a and Hoxc8 were coexpressed. Recent genome-wide studies identified Zfp804a (or ZNF804A in humans) as a plausible marker for schizophrenia, leading us to hypothesize that this embryogenic regulatory control might also exert influence in development of complex traits such as psychosis
Files in This Item:
T201001168.pdf Download
DOI
10.1155/2010/231708
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
Min, Hye Hyun(민혜현) ORCID logo https://orcid.org/0000-0001-5450-5088
Lee, Ji Yeon(이지연) ORCID logo https://orcid.org/0000-0002-0670-3095
Chung, Huyun Joo(정현주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/101007
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