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Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8

DC FieldValueLanguage
dc.contributor.author김명희-
dc.contributor.author민혜현-
dc.contributor.author이지연-
dc.contributor.author정현주-
dc.date.accessioned2015-04-23T16:40:17Z-
dc.date.available2015-04-23T16:40:17Z-
dc.date.issued2010-
dc.identifier.issn1110-7243-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/101007-
dc.description.abstractUsing a ChIP-cloning technique, we identified a Zinc finger protein 804a (Zfp804a) as one of the putative Hoxc8 downstream target genes. We confirmed binding of Hoxc8 to an intronic region of Zfp804a by ChIP-PCR in F9 cells as well as in mouse embryos. Hoxc8 upregulated Zfp804a mRNA levels and augmented minimal promoter activity in vitro. In E11.5 mouse embryos, Zfp804a and Hoxc8 were coexpressed. Recent genome-wide studies identified Zfp804a (or ZNF804A in humans) as a plausible marker for schizophrenia, leading us to hypothesize that this embryogenic regulatory control might also exert influence in development of complex traits such as psychosis-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfJournal of Biomedicine & Biotechnology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorHyun Joo Chung-
dc.contributor.googleauthorJi-Yeon Lee-
dc.contributor.googleauthorCuster C. Deocaris-
dc.contributor.googleauthorHyehyunMin-
dc.contributor.googleauthorSang Hoon Kim-
dc.contributor.googleauthorMyoung Hee Kim-
dc.identifier.doi10.1155/2010/231708-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00432-
dc.contributor.localIdA01416-
dc.contributor.localIdA03769-
dc.contributor.localIdA03194-
dc.relation.journalcodeJ01270-
dc.identifier.pmid20508826-
dc.contributor.alternativeNameKim, Myoung Hee-
dc.contributor.alternativeNameMin, Hye Hyun-
dc.contributor.alternativeNameLee, Ji Yeon-
dc.contributor.alternativeNameChung, Huyun Joo-
dc.contributor.affiliatedAuthorKim, Myoung Hee-
dc.contributor.affiliatedAuthorMin, Hye Hyun-
dc.contributor.affiliatedAuthorChung, Huyun Joo-
dc.contributor.affiliatedAuthorLee, Ji Yeon-
dc.citation.volume2010-
dc.citation.startPage231708-
dc.identifier.bibliographicCitationJournal of Biomedicine & Biotechnology, Vol.2010 : 231708, 2010-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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